Results 91 to 100 of about 213,884 (312)

Genetic variation and hybridization determine the outcomes of conservation reintroductions

Conservation Letters
The preservation of genetic variation is fundamental in biodiversity conservation, yet its importance for population viability remains contentious.
Colter A. Feuerstein, Ryan P. Kovach, Carter G. Kruse, Matt E. Jaeger, Donovan A. Bell, Zachary L. Robinson, Andrew R. Whiteley   +6 more
doaj   +1 more source

Males influence maternal effects that promote sexual selection : a quantitative genetic experiment with dung beetles Onthophagus taurus

, 2014
J.S.K. was funded by the Academy of Finland, L.W.S. by the Australian Research Council, J.H. by an Australian Postgraduate Award, and J.L.T. by a postdoctoral research fellowship from the University of Western Australia.Recently, doubt has been cast on ...
Simmons, LW, Tomkins, Joseph Leopold, Hunt, J, Kotiahl, JS   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fitness Clouds and Problem Hardness in Genetic Programming [PDF]

, 2004
This paper presents an investigation of genetic programming fitness landscapes. We propose a new indicator of problem hardness for tree-based genetic programming, called negative slope coefficient, based on the concept of fitness cloud. The negative slope coefficient is a predictive measure, i.e.
Leonardo Vanneschi, Manuel Clergue, Philippe Collard, Marco Tomassini, Sébastien Vérel   +4 more
openaire   +2 more sources

Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities

Cell Reports
Summary: Among the fundamental questions in sexual reproduction are how fitness is inherited and whether parents exhibit differential mating affinities.
Sivan Kaminski Strauss, Ruthie Golomb, Donya Khoury, Noa Aharon-Hefetz, Hadar Meyer, Dayag Sheykhkarimli, Gianni Liti, Orna Dahan, Yitzhak Pilpel   +8 more
doaj   +1 more source

Genomic–based optimum contribution in conservation and genetic improvement programs with antagonistic fitness and productivity traits

Frontiers in Genetics, 2016
Animal selection for genetic improvement of productivity may lead to an increase in inbreeding through the use of techniques that enhance the reproductive capability of selected animals.
Enrique eSanchez-Molano, Ricardo ePong-Wong, Georgios eBanos, Georgios eBanos, Georgios eBanos   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Discrete Evolutionary Genetics: Multiplicative Fitnesses and the Mutation-Fitness Balance

Applied Mathematics, 2011
We revisit the multi-allelic mutation-fitness balance problem especially when fitnesses are multiplicative. Using ideas arising from quasi-stationary distributions, we analyze the qualitative differences between the fitness-first and mutation-first models, under various schemes of the mutation pattern.
Huillet, Thierry, Martinez, Servet
openaire   +2 more sources

Accumulation of Deleterious Mutations Near Sexually Antagonistic Genes

G3: Genes, Genomes, Genetics, 2016
Mutation generates a steady supply of genetic variation that, while occasionally useful for adaptation, is more often deleterious for fitness. Recent research has emphasized that the fitness effects of mutations often differ between the sexes, leading to
Tim Connallon, Crispin Y. Jordan
doaj   +1 more source

Genetic Programming with Guaranteed Constraints [PDF]

, 2002
Genetic programming is a powerful technique for automatically generating program code from a description of the desired functionality. However it is frequently distrusted by users because the programs are generated with reference to a training set, and ...
Johnson, Colin G.
core