Results 71 to 80 of about 492,575 (295)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds. [PDF]
PLoS Pathogens, 2015 Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting infectious diseases. Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time.
Wan-Lin Yang +12 more
doaj +1 more source
Computational Universality and 1/f Noise in Elementary Cellular Automata [PDF]
, 2013 It is speculated that there is a relationship between 1/f noise and computational universality in cellular automata. We use genetic algorithms to search for one-dimensional and two-state, five-neighbor cellular automata which have 1/f-type spectrum.
Ninagawa, Shigeru
core +1 more source
Quantitative genetics and fitness: lessons from Drosophila [PDF]
Heredity, 1987 This paper examines patterns of heritability and genetic covariance between traits in the genus Drosophila. Traits are divided into the categories, morphology, behaviour, physiology and life history. Early theoretical analyses suggested that life history traits should have heritabilities that are lower than those in other categories.
D A, Roff, T A, Mousseau
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Causal associations between cardiorespiratory fitness and type 2 diabetes
Nature Communications, 2023 Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However, the causality of this relationship and the biological mechanisms that underlie it are unclear.
Lina Cai +8 more
doaj +1 more source
Functional relevance of the newly evolved sperm dynein intermediate chain multigene family in Drosophila melanogaster males. [PDF]
, 2012 In many animal species, traits associated with male fitness evolve rapidly. Intersexual conflict and male-male competition have been suggested to drive this rapid evolution.
Abbassi, Mashya +3 more
core +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Evolving text classification rules with genetic programming [PDF]
, 2005 We describe a novel method for using genetic programming to create compact classification rules using combinations of N-grams (character strings). Genetic programs acquire fitness by producing rules that are effective classifiers in terms of precision ...
Anthony N. +14 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source