Results 71 to 80 of about 213,884 (312)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
On the Consequences of Purging and Linkage on Fitness and Genetic Diversity [PDF]
G3 Genes|Genomes|Genetics, 2016 AbstractUsing computer simulation we explore the consequences of linkage on the inbreeding load of an equilibrium population, and on the efficiency of purging and the loss of genetic diversity after a reduction in population size. We find that linkage tends to cause increased inbreeding load due to the build up of coupling groups of (partially ...
Bersabé García, Diego +3 more
openaire +4 more sources
Within-plant genetic drift to control virus adaptation to host resistance genes.
PLoS PathogensManipulating evolutionary forces imposed by hosts on pathogens like genetic drift and selection could avoid the emergence of virulent pathogens. For instance, increasing genetic drift could decrease the risk of pathogen adaptation through the random ...
Lucie Tamisier +8 more
doaj +1 more source
Silva Fennica, 2016 Extant populations growing in regions that were refugia during the last glacial period are expected to show higher genetic diversity than populations that moved from these refugia into new areas in higher latitudes.
Valdir Stefenon +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds. [PDF]
PLoS Pathogens, 2015 Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting infectious diseases. Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time.
Wan-Lin Yang +12 more
doaj +1 more source
Fitness consequences of avian personalities in a fluctuating environment [PDF]
, 2004 1. Intraspecific variation in reproductive decisions is generally considered as a reaction to environmental circumstances. We show that variation in reproductive parameters also covaries with intraspecific variation in personality. 2.
Both, C. +15 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Causal associations between cardiorespiratory fitness and type 2 diabetes
Nature Communications, 2023 Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However, the causality of this relationship and the biological mechanisms that underlie it are unclear.
Lina Cai +8 more
doaj +1 more source
Adaptive group mutation for tackling deception in genetic search [PDF]
, 2004 Copyright @ 2004 WSEASIn order to study the efficacy of genetic algorithms (GAs), a number of fitness landscapes have been designed and used as test functions.
Yang, S, Yang, Shengxiang
core