Results 71 to 80 of about 186,500 (263)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Genetic stereo matching algorithm with fuzzy fitness [PDF]
2014 6th International Conference of Soft Computing and Pattern Recognition (SoCPaR), 2014 This paper presents a genetic stereo matching algorithm with fuzzy evaluation function. The proposed algorithm presents a new encoding scheme in which a chromosome is represented by a disparity matrix. Evolution is controlled by a fuzzy fitness function able to deal with noise and uncertain camera measurements, and uses classical evolutionary operators.
openaire +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Using Fitness Value for Monitoring Kiwifruit’s Variant Seedling in Tissue Culture
Cybernetics and Information Technologies, 2016 Based on Genetic Algorithm, a pattern recognition approach using fitness to dynamically monitor the sub cultured seeding of kiwifruit is proposed in order to decrease the loss of variant seedlings in tissue culture.
Tang Shouguo, Li Yong, Zhang Zhikun
doaj +1 more source
Fitness uniform selection to preserve genetic diversity [PDF]
Proceedings of the 2002 Congress on Evolutionary Computation. CEC'02 (Cat. No.02TH8600), 2003 13 LaTeX pages, 1 eps ...
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Accumulation of Deleterious Mutations Near Sexually Antagonistic Genes
G3: Genes, Genomes, Genetics, 2016 Mutation generates a steady supply of genetic variation that, while occasionally useful for adaptation, is more often deleterious for fitness. Recent research has emphasized that the fitness effects of mutations often differ between the sexes, leading to
Tim Connallon, Crispin Y. Jordan
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source