Results 51 to 60 of about 213,884 (312)
Population bottlenecks constrain host microbiome diversity and genetic variation impeding fitness.
PLoS Genetics, 2022 It is becoming increasingly clear that microbial symbionts influence key aspects of their host's fitness, and vice versa. This may fundamentally change our thinking about how microbes and hosts interact in influencing fitness and adaptation to changing ...
Michael Ørsted +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Direct selection on genetic robustness revealed in the yeast transcriptome. [PDF]
PLoS ONE, 2007 Evolutionary theory predicts that organisms should evolve the ability to produce high fitness phenotypes in the face of environmental disturbances (environmental robustness) or genetic mutations (genetic robustness).
Stephen R Proulx +2 more
doaj +1 more source
A building-block Royal Road where crossover is provably essential
, 2007 One of the most controversial yet enduring hypotheses about what genetic algorithms (GAs) are good for concerns the idea that GAs process building-blocks.
Richard A. Watson +3 more
core +1 more source
Efficient genetic algorithms for solving hard constrained optimization problems [PDF]
, 2000 This paper studies many Genetic Algorithm strategies to solve hard-constrained optimization problems. It investigates the role of various genetic operators to avoid premature convergence. In particular, an analysis of niching methods is carried out on a
Sareni, Bruno +2 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Putting genetic variants to a fitness test [PDF]
Nature Reviews Genetics, 2018 Two studies report the application of high-throughput genome editing approaches to engineer many precise genetic variants and determine their functional impact in human and yeast cells.
openaire +2 more sources
Evolution of genetic redundancy: the relevance of complexity in genotype–phenotype mapping
New Journal of Physics, 2014 Despite its ubiquity among organisms, genetic redundancy is presumed to reduce total population fitness and is therefore unlikely to evolve. This study evaluates an evolutionary model with high-dimensional genotype–phenotype mapping (GPM) by applying a ...
Nen Saito +2 more
doaj +1 more source
Family Medicine and Community Health, 2018 The Saudi genome project started in 2013 with a great hope to improve medical care and disease prevention. Among the genes are those related to nutrition and fitness that can optimize an individual’s lifestyle.
Faten Dhawi, Faisal Shehab Alotaibi
doaj +1 more source
BMC Biology, 2021 Background Apomixis, the asexual reproduction through seeds, occurs in over 40 plant families and avoids the hidden cost of sex. Apomictic plants are thought to have an advantage in sparse populations and when colonizing new areas but may have a ...
Christian Sailer +4 more
doaj +1 more source