Results 31 to 40 of about 492,575 (295)

Rare-event sampling analysis uncovers the fitness landscape of the genetic code.

PLoS Computational Biology, 2023
The genetic code refers to a rule that maps 64 codons to 20 amino acids. Nearly all organisms, with few exceptions, share the same genetic code, the standard genetic code (SGC).
Yuji Omachi, Nen Saito, Chikara Furusawa
doaj   +1 more source

Genetic algorithm dynamics on a rugged landscape

, 1999
The genetic algorithm is an optimization procedure motivated by biological evolution and is successfully applied to optimization problems in different areas.
A. E. Nix, A. M. Turing, A. Prügel-Bennett, A. Prügel-Bennett, B. Derrida, B. Manderick, C. R. Darwin, E. Aarts, G. J. Friedman, G. J. Koehler, J. H. Holland, J. von Neumann, M. D. Vose, M. Rattray, N. Wiener, P. Sutton, S. Bornholdt, S. Kauffman, S. Kauffman, Stefan Bornholdt   +19 more
core   +1 more source

An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape.

PLoS Genetics, 2019
Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms.
Victoria O Pokusaeva, Dinara R Usmanova, Ekaterina V Putintseva, Lorena Espinar, Karen S Sarkisyan, Alexander S Mishin, Natalya S Bogatyreva, Dmitry N Ivankov, Arseniy V Akopyan, Sergey Ya Avvakumov, Inna S Povolotskaya, Guillaume J Filion, Lucas B Carey, Fyodor A Kondrashov   +13 more
doaj   +1 more source

Loss of ecologically important genetic variation in late generation hybrids reveals links between adaptation and speciation

Evolution Letters, 2020
Adaptation to contrasting environments occurs when advantageous alleles accumulate in each population, but it remains largely unknown whether these same advantageous alleles create genetic incompatibilities that can cause intrinsic reproductive isolation
Greg M. Walter, Thomas J. Richards, Melanie J Wilkinson, Mark W. Blows, J. David Aguirre, Daniel Ortiz‐Barrientos   +5 more
doaj   +1 more source

Properties of selected mutations and genotypic landscapes under Fisher's Geometric Model

, 2014
The fitness landscape - the mapping between genotypes and fitness - determines properties of the process of adaptation. Several small genetic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness
Achaz, Guillaume, Bataillon, Thomas, Blanquart, François, Tenaillon, Olivier   +3 more
core   +1 more source

Additive genetic variance for traits least related to fitness increases with environmental stress in the desert locust, Schistocerca gregaria

Ecology and Evolution, 2021
Under environmental stress, previously hidden additive genetic variation can be unmasked and exposed to selection. The amount of hidden variation is expected to be higher for life history traits, which strongly correlate to individual fitness, than for ...
Marie‐Pierre Chapuis, Benjamin Pélissié, Cyril Piou, Floriane Chardonnet, Christine Pagès, Antoine Foucart, Elodie Chapuis, Hélène Jourdan‐Pineau   +7 more
doaj   +1 more source

Effects of Epistasis and Pleiotropy on Fitness Landscapes

, 2013
The factors that influence genetic architecture shape the structure of the fitness landscape, and therefore play a large role in the evolutionary dynamics. Here the NK model is used to investigate how epistasis and pleiotropy -- key components of genetic
A Dawid, AI Khan, B Østman, DJ Kvitek, FJ Poelwijk, H Chou, HA Orr, MC Whitlock, MC Whitlock, MM Desai, RL Unckless, S Gavrilets, S Gavrilets, S Kauffman, S Kauffman, V Mustonen   +15 more
core   +1 more source

Feasibility and reliability of a Physical Fitness test battery in individuals with Down Syndrome [PDF]

, 2019
Background: Down syndrome (DS) is a genetic disorder that occurs because of an abnormal division between cells that results in an extra copy of chromosome 21.
Alcántara Cordero, Francisco Javier, Cabeza Ruiz, Ruth, Ruiz Gavilán, Isaac, Sánchez López, Antonio Manuel   +3 more
core   +1 more source

Cross‐sex genetic correlations for fitness and fitness components: Connecting theoretical predictions to empirical patterns

Evolution Letters, 2019
Sex differences in morphology, physiology, development, and behavior are widespread, yet the sexes inherit nearly identical genomes, causing most traits to exhibit strong and positive cross‐sex genetic correlations.
Tim Connallon, Genevieve Matthews
doaj   +1 more source

Dynamic fitness landscapes: Expansions for small mutation rates [PDF]

, 2000
We study the evolution of asexual microorganisms with small mutation rate in fluctuating environments, and develop techniques that allow us to expand the formal solution of the evolution equations to first order in the mutation rate.
Demetrius, Drake, Eigen, Eigen, Eigen, Jones, Jones, Leuthäusser, Levin, Nilsson, Ronnewinkel, Swetina, Tarazona, Wilke, Yoshimura   +14 more
core   +3 more sources