Results 61 to 70 of about 492,575 (295)

Local Fitness Landscape Exploration Based Genetic Algorithms

IEEE Access, 2023
Genetic algorithms (GAs) have been used to evolve optimal/sub-optimal solutions of many problems. When using GAs for evolving solutions, often fitness evaluation is the most computationally expensive, and this discourages researchers from applying GAs for computationally challenging problems.
Dubey, Rahul, Hickinbotham, Simon John, Price, Mark, Tyrrell, Andy   +3 more
openaire   +5 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Male-benefit sexually antagonistic genotypes show elevated vulnerability to inbreeding

BMC Evolutionary Biology, 2017
Background There is theoretical and empirical evidence for strong sexual selection in males having positive effects on population viability by serving to purify the genome of its mutation load at a low demographic cost. However, there is also theoretical
Karl Grieshop, David Berger, Göran Arnqvist   +2 more
doaj   +1 more source

Evolutionary accessibility in tunably rugged fitness landscapes

, 2012
The adaptive evolution of a population under the influence of mutation and selection is strongly influenced by the structure of the underlying fitness landscape, which encodes the interactions between mutations at different genetic loci.
Franke, Jasper, Krug, Joachim
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Red Queen Coevolution on Fitness Landscapes

, 2013
Species do not merely evolve, they also coevolve with other organisms. Coevolution is a major force driving interacting species to continuously evolve ex- ploring their fitness landscapes. Coevolution involves the coupling of species fit- ness landscapes,
A. Hastings, A. Hoffman, A. Ilachinsky, A. Kerr, A.A. Berryman, A.F. Agrawal, A.F. Agrawal, B. Drossel, C. Darwin, C.M. Lively, D.J. Mode, D.K. Clarke, D.M. Raup, D.M. Raup, E. Decaestecker, F. Dercole, F. Jacob, F. Jacob, G. Lafforgue, G. Nicolis, H. Freund, H. Haken, H.H. Flor, J. Jaenike, J. Quer, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Sardanyés, J. Seger, J.A.G.M. Visser de, J.B.S. Haldane, J.M. Montoya, J.N. Thompson, J.N. Thompson, J.N. Thompson, J.N. Thompson, J.S. McCaskill, J.S. Weltz, K. Kaneko, K.C. King, K.Y. Yip, L. Valen Van, L. Valen Van, L. Valen Van, L.T. Morran, M. Eigen, M. Pascual, M. Tegmark, M.A. Parker, M.E.J. Newman, M.J. Benton, N.C. Stenseth, P. Bak, P.D. Roopnarine, P.R. Ehrlich, R. Ferrière, R.K. Grosberg, R.M. May, R.S. Howard, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, R.V. Solé, S. Wright, S. Wright, S.A. Kauffman, S.A. Kauffman, S.C. Manrubia, S.F. Elena, S.J. Gould, T. Dobzhansky, T. Ikegami, T.J. Case, U. Dieckmann, W.D. Hamilton, W.D. Hamilton, W.H. Li, Z.Q. Chen   +88 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Within-plant genetic drift to control virus adaptation to host resistance genes.

PLoS Pathogens
Manipulating evolutionary forces imposed by hosts on pathogens like genetic drift and selection could avoid the emergence of virulent pathogens. For instance, increasing genetic drift could decrease the risk of pathogen adaptation through the random ...
Lucie Tamisier, Frédéric Fabre, Marion Szadkowski, Lola Chateau, Ghislaine Nemouchi, Grégory Girardot, Pauline Millot, Alain Palloix, Benoît Moury   +8 more
doaj   +1 more source

Evidences of genetic bottleneck and fitness decline in Luehea divaricata populations from southern Brazil

Silva Fennica, 2016
Extant populations growing in regions that were refugia during the last glacial period are expected to show higher genetic diversity than populations that moved from these refugia into new areas in higher latitudes.
Valdir Stefenon, Jordana Nagel, Igor Poletto   +2 more
doaj   +1 more source

Genetic algorithms with noisy fitness

Mathematical and Computer Modelling, 1996
This paper is devoted to the convergence analysis of genetic algorithms with noisy fitness information. Since the identification of the best individual in each generation is needed, one has to decide which individual has maximal fitness. In the proposed scheme, sign tests are used to compare sample fitness values.
Zhai, W, Kelly, P, Gong, WB
openaire   +3 more sources