Results 61 to 70 of about 186,500 (263)

Improved Genetic Algorithm to Reduce Mutation Testing Cost

IEEE Access, 2017
Mutation testing is a fault-based testing technique that helps generating effective test cases. Mutation testing is computationally expensive, because it requires executing hundreds and even thousands of mutants.
Muhammad Bilal Bashir, Aamer Nadeem
doaj   +1 more source

Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds. [PDF]

PLoS Pathogens, 2015
Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting infectious diseases. Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time.
Wan-Lin Yang, Roger D Kouyos, Jürg Böni, Sabine Yerly, Thomas Klimkait, Vincent Aubert, Alexandra U Scherrer, Mohaned Shilaih, Trevor Hinkley, Christos Petropoulos, Sebastian Bonhoeffer, Huldrych F Günthard, Swiss HIV Cohort Study (SHCS)   +12 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Genetic variation and hybridization determine the outcomes of conservation reintroductions

Conservation Letters
The preservation of genetic variation is fundamental in biodiversity conservation, yet its importance for population viability remains contentious.
Colter A. Feuerstein, Ryan P. Kovach, Carter G. Kruse, Matt E. Jaeger, Donovan A. Bell, Zachary L. Robinson, Andrew R. Whiteley   +6 more
doaj   +1 more source

Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities

Cell Reports
Summary: Among the fundamental questions in sexual reproduction are how fitness is inherited and whether parents exhibit differential mating affinities.
Sivan Kaminski Strauss, Ruthie Golomb, Donya Khoury, Noa Aharon-Hefetz, Hadar Meyer, Dayag Sheykhkarimli, Gianni Liti, Orna Dahan, Yitzhak Pilpel   +8 more
doaj   +1 more source

Fitness Clouds and Problem Hardness in Genetic Programming [PDF]

, 2004
This paper presents an investigation of genetic programming fitness landscapes. We propose a new indicator of problem hardness for tree-based genetic programming, called negative slope coefficient, based on the concept of fitness cloud. The negative slope coefficient is a predictive measure, i.e.
Leonardo Vanneschi, Manuel Clergue, Philippe Collard, Marco Tomassini, Sébastien Vérel   +4 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genomic–based optimum contribution in conservation and genetic improvement programs with antagonistic fitness and productivity traits

Frontiers in Genetics, 2016
Animal selection for genetic improvement of productivity may lead to an increase in inbreeding through the use of techniques that enhance the reproductive capability of selected animals.
Enrique eSanchez-Molano, Ricardo ePong-Wong, Georgios eBanos, Georgios eBanos, Georgios eBanos   +4 more
doaj   +1 more source

Discrete Evolutionary Genetics: Multiplicative Fitnesses and the Mutation-Fitness Balance

Applied Mathematics, 2011
We revisit the multi-allelic mutation-fitness balance problem especially when fitnesses are multiplicative. Using ideas arising from quasi-stationary distributions, we analyze the qualitative differences between the fitness-first and mutation-first models, under various schemes of the mutation pattern.
Huillet, Thierry, Martinez, Servet
openaire   +2 more sources