Results 131 to 140 of about 5,638,229 (338)

Effective population size and genetic gain expected in a population of Coffea canephora

Crop Breeding and Applied Biotechnology, 2019
This work aimed to study the effective population size and genetic gain in a population of robusta coffee (Coffea canephora Pierre) and verify the possibility of using recurrent selection.
J. C. Mistro, M. Resende, L. C. Fazuoli, R. Vencovsky   +3 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Genetic selection for hoof health traits and cow mobility scores can accelerate the rate of genetic gain in producer-scored lameness in dairy cows.

Journal of Dairy Science, 2018
Cattle breeding programs that strive to reduce the animal-level incidence of lameness are often hindered by the availability of informative phenotypes.
S. Ring, A. Twomey, N. Byrne, M. Kelleher, T. Pabiou, M. Doherty, D. Berry   +6 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Histórico genético e populacional do rebanho Nelore Puro de Origem no Sertão Nordestino Genetic and populational background of Pure Nelore cattle breed in Brazilian Northeastern Sertão

Pesquisa Agropecuária Brasileira, 2009
O objetivo deste trabalho foi avaliar o histórico do rebanho Nelore Puro de Origem no Sertão Nordestino por meio da determinação de sua estrutura populacional e da quantificação do progresso genético, fenotípico e ambiental ocorrido em características de
Carlos Henrique Mendes Malhado, Paulo Luiz Souza Carneiro, Raimundo Martins Filho, Danielle Maria Machado Ribeiro Azevedo   +3 more
doaj   +1 more source

Genetic improvement of silage maize: predicting genetic gain using selection indexes and best linear unbiased prediction

Revista Ciência Agronômica, 2019
The objective of this study was to evaluate four selection indexes and best linear unbiased prediction (BLUP) for predicting genetic gain in maize hybrids used for silage. The genetic gain was compared between four selection indexes and BLUP.
Jocarla Ambrosim Crevelari, M. G. Pereira, Flávio Henrique Vidal Azevedo, R. Vieira   +3 more
semanticscholar   +1 more source

New insights into genomic selection through population-based non-parametric prediction methods

Scientia Agricola
: Genome-wide selection (GWS) is based on a large number of markers widely distributed throughout the genome. Genome-wide selection provides for the estimation of the effect of each molecular marker on the phenotype, thereby allowing for the capture of ...
Leísa Pires Lima, Camila Ferreira Azevedo, Marcos Deon Vilela de Resende, Fabyano Fonseca e Silva, Matheus Massariol Suela, Moysés Nascimento, José Marcelo Soriano Viana   +6 more
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source