Results 231 to 240 of about 6,603,978 (370)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Realized genetic gain for yield and yield attributes in groundnut breeding at ICRISAT from an ERA trial. [PDF]

Front Plant Sci
Behera PP, Deshmukh D, Vemula AK, Bangaru K, Bagudam R, Mathew A, Purohit A, Vishnumolakala A, Wankhade AP, Kounain S, Guguloth N, Variath MT, Kurva M, Potupureddi G, Muragesan S, Raman A, Pasupuleti J.   +16 more
europepmc   +1 more source

Gene action, genetic parameters and selection gain of physical attributes related to grain quality in rice

, 2021
Paulo Henrique Karling Facchinello
openalex   +1 more source

Microevolution and Gain or Loss of Mobile Genetic Elements of Outbreak-Related Listeria monocytogenes in Food Processing Environments Identified by Whole Genome Sequencing Analysis [PDF]

, 2020
Helen H. Yang, Maria Hoffmann, Marc W. Allard, Eric W. Brown, Yi Chen   +4 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

How partial phenotyping to reduce generation intervals can help to increase annual genetic gain in selected honeybee populations. [PDF]

Heredity (Edinb)
Kistler T, Brascamp EW, Basso B, Phocas F, Bijma P.   +4 more
europepmc   +1 more source

Effect of weight gain, of the cutting type and of the genetic group in the quality of meat goats in the Ceará States

, 2001
Luciana Fujiwara de Aguiar
openalex   +1 more source

Genetic parameters and estimated genetic gains in young rubber tree progenies [PDF]

, 2013
Cecília Khusala Verardi, Erivaldo José Scaloppi, Guilherme Augusto Peres Silva, Lígia Regina Lima Gouvêa, Paulo de Souza Gonçalves   +4 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source