Results 81 to 90 of about 6,603,978 (370)

TLR7 gain-of-function genetic variation causes human lupus

Nature, 2022
Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease1–7, evidence of lupus-causing TLR7 gene variants is lacking. Here we describe human systemic lupus erythematosus
G. Brown, Pablo F Cañete, Hao Wang, Arti Medhavy, J. Bones, Jonathan A. Roco, Yuke He, Y. Qin, J. Cappello, J. Ellyard, Katharine Bassett, Q. Shen, G. Burgio, Yaoyuan Zhang, C. Turnbull, Xian-Ce Meng, Philip Wu, Eun Cho, L. Miosge, T. Andrews, Matt A. Field, D. Tvorogov, A. Lopez, J. Babon, C. A. López, Á. Gónzalez-Murillo, D. C. Garulo, V. Pascual, T. Levy, E. Mallack, D. Calame, T. Lotze, J. Lupski, Huihua Ding, Tomalika R. Ullah, G. Walters, M. Koina, M. Cook, N. Shen, C. de Lucas Collantes, B. Corry, M. Gantier, V. Athanasopoulos, C. Vinuesa   +43 more
semanticscholar   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Concurrent enhancement of provitamin A and yield in tropical maize hybrids

Frontiers in Plant Science
Maize is a strategic food crop in sub-Saharan Africa, where vitamin A deficiency affects millions. Significant investments have thus focused on developing maize varieties that provide 50% of the daily vitamin A requirement for vulnerable populations ...
Abebe Menkir, Ibnou Dieng, Silvestro Meseka, Bussie Maziya-Dixon, Bunmi Bossey, Oyekunle Muhyideen, Manfred Ewool, Mmadou Coulibaly, Wende Mengesha   +8 more
doaj   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Bias in the prediction of genetic gain due to mass and half-sib selection in random mating populations

Genetics and Molecular Biology, 2009
The prediction of gains from selection allows the comparison of breeding methods and selection strategies, although these estimates may be biased. The objective of this study was to investigate the extent of such bias in predicting genetic gain. For this,
José Marcelo Soriano Viana, Vinícius Ribeiro Faria, Admilson da Costa e Silva   +2 more
doaj  

Evolution of Sweet Potato (Ipomoea batatas [L.] Lam.) Breeding in Cuba

Plants
This study analyzed the genetic progress of sweet potato (Ipomoea batatas) breeding in Cuba over the past 50 years by field trials comparing traditional and improved varieties.
Alfredo Morales, Peiyong Ma, Zhaodong Jia, Dania Rodríguez, Iván Javier Pastrana Vargas, Vaniert Ventura, José Efraín González, Orelvis Portal, Federico Diaz, Oscar Parrado Alvarez, Carina Cordero, Xiaofeng Bian   +11 more
doaj   +1 more source

Integrating genomic selection into dairy cattle breeding programmes: a review

Animal, 2013
Extensive genetic progress has been achieved in dairy cattle populations on many traits of economic importance because of efficient breeding programmes.
A. Bouquet, J. Juga
doaj   +1 more source

Let the consumer decide? The regulation of commercial genetic testing. [PDF]

, 2001
Objectives—The development of predictive genetic tests provides a new area where consumers can gain knowledge of their health status and commercial opportunities.
Levitt, M. I.
core   +3 more sources

Genotype x environment interaction and genetic gain for grain yield and grain quality traits in Turkish spring wheat released between 1964 and 2010

PLoS ONE, 2019
The study was conducted to determine the effects of genotype (G), environment (E), their interaction (GEI) and genetic gain on yield and grain quality traits in Turkish spring wheat cultivars released between 1964 and 2010.
A. Nehe, B. Akin, T. Şanal, A. K. Evlice, R. Ünsal, N. Dinçer, L. Demir, H. Geren, Ismail Sevim, Şinasi Orhan, Ş. Yaktubay, A. Ezici, C. Guzmán, A. Morgounov   +13 more
semanticscholar   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source