Results 101 to 110 of about 53,278 (329)

Epilepsy – A Brief Overview [PDF]

, 2005
Epilepsy is a neurological condition in which an individual experiences chronic abnormal bursts of electrical discharge in the brain. These seizures can cause a variety symptoms depending on the areas of the brain affected. Symptoms can vary from mild to
Koyama, Alain
core  

White Matter Abnormalities in Patients with Treatment-Resistant Genetic Generalized Epilepsies. [PDF]

, 2016
BACKGROUND Genetic generalized epilepsies (GGEs) are associated with microstructural brain abnormalities that can be evaluated with diffusion tensor imaging (DTI). Available studies on GGEs have conflicting results.
Allendorfer, Jane B, Deutsch, Georg, Gaston, Tyler E, Knowlton, Robert C, Lee, Seongtaek, Pati, Sandipan, Szaflarski, Jerzy P, Ver Hoef, Lawrence W   +7 more
core   +2 more sources

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

TRIM39-RPP21 Variants (∆19InsCCC) Are Not Associated with Juvenile Idiopathic Epilepsy in Egyptian Arabian Horses. [PDF]

, 2019
Juvenile idiopathic epilepsy (JIE) is an inherited disease characterized by recurrent seizures during the first year of life in Egyptian Arabian horses. Definitive diagnosis requires an electroencephalogram (EEG) performed by a veterinary specialist.
Aleman, Monica, Dahlgren, Anna R, Finno, Carrie J, Hales, Erin N, Peterson, Janel A, Rivas, Victor N   +5 more
core   +2 more sources

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population.

PLoS ONE, 2020
Epilepsy is clinically heterogeneous, and neurological or psychiatric comorbidities are frequently observed in patients. It has not been tested whether common risk variants for generalized or focal epilepsy are enriched in people with other disorders or ...
Costin Leu, Tom G Richardson, Tobias Kaufmann, Dennis van der Meer, Ole A Andreassen, Lars T Westlye, Robyn M Busch, George Davey Smith, Dennis Lal   +8 more
doaj   +1 more source

Clinical features, proximate causes, and consequences of active convulsive epilepsy in Africa. [PDF]

, 2013
PURPOSE: Epilepsy is common in sub-Saharan Africa (SSA), but the clinical features and consequences are poorly characterized. Most studies are hospital-based, and few studies have compared different ecological sites in SSA. We described active convulsive
Adjei, Patrick, Ae-Ngibise, Ken, Agbokey, Francis, Akpalu, Albert, Akpalu, Bright, Bauni, Evasius, Bottomley, Christian, Chabi, Martin, Chengo, Eddie, Collinson, Mark, Connor, Myles, Doku, Victor CK, Gómez Olivé, F Xavier, Kahn, Kathleen, Kakooza-Mwesige, Angelina, Kamuyu, Gathoni, Kariuki, Symon M, Kleinschmidt, Immo, Mageto, James O, Masanja, Honratio, Mathew, Alexander, Matuja, William, Ndyomughenyi, Donald, Neville, Brian GR, Newton, Charles RJC, Ngugi, Anthony K, Noh, John, Nutman, Thomas, Odera, Victor Mung'ala, Odermatt, Peter, Odhiambo, Rachael, Owusu-Agyei, Seth, Pariyo, George, Peterson, Stefan, Sander, Josemir W, SEEDS writing group, Tollman, Stephen, Twine, Rhian, Wagner, Ryan G, White, Steven, Wilkins, Patricia   +40 more
core   +1 more source

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Advanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu, Philippa J. Karoly, Sina Mansour L., Artemio Soto‐Breceda, Levin Kuhlmann, Mark J. Cook, David B. Grayden   +6 more
wiley   +1 more source

The long-term prognosis of epilepsy patients with medically treated over a period of eight years in Turkey. [PDF]

, 2017
OBJECTIVE:The aim of this study was to investigate the effect of demographic and clinical characteristics on temporal changes in seizure control and frequency in medically treated epilepsy patients to guide treatment modalities.
Duman, Pelin, Kurum, Esra, Varoglu, Asuman Orhan   +2 more
core   +1 more source