Results 81 to 90 of about 2,936,182 (239)

Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population.

PLoS ONE, 2020
Epilepsy is clinically heterogeneous, and neurological or psychiatric comorbidities are frequently observed in patients. It has not been tested whether common risk variants for generalized or focal epilepsy are enriched in people with other disorders or ...
Costin Leu, Tom G Richardson, Tobias Kaufmann, Dennis van der Meer, Ole A Andreassen, Lars T Westlye, Robyn M Busch, George Davey Smith, Dennis Lal   +8 more
doaj   +1 more source

A Multi‐Scale Computational Framework for Evaluating Wireless Neuromodulation Feasibility via Magnetoelectric Nanoparticles

Advanced Science, EarlyView.
A multiscale computational framework links single‐nanoparticle magnetoelectric behavior to tissue‐level electric field distributions, integrating experimental data from nanoparticle characterization and in vitro stimulation setups. Applied to a cortical slice configuration, the framework predicts optimal MENP concentrations and stimulation parameters ...
Marta Bonato, Elric Zhang, Emma Chiaramello, Serena Fiocchi, Giulia Suarato, Valentin Gantenbein, Nathalia Cancino‐Fuentes, Alejandro Suarez‐Perez, Maria V. Sanchez‐Vives, Salvador Pané, Marta Parazzini   +10 more
wiley   +1 more source

Management and outcomes among older adults with generalized epilepsy in routine clinical practice

Epilepsia Open
Generalized epilepsy is classically thought of as a disease of the young and adolescent, with rarely reported cases among older adults. We aimed to analyze management and outcomes in a population sparsely described in the literature through a ...
MarieElena Byrnes, Majed Alzahrany, Vineet Punia   +2 more
doaj   +1 more source

Functional Imaging in Idiopathic/Genetic Generalized Epilepsies. [PDF]

, 2023
Genetic generalized epilepsies affect approximately 15 million people worldwide. Seizures can range from generalized tonic-clonic seizures to absence seizures to myoclonic seizures.
Wagner, Benjamin,
core  

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Statins' protective effects on focal epilepsy are independent of LDL‐C

Epilepsia Open
Objective This study evaluates the potential protective effects of statins against epilepsy, focusing on their differential impacts on focal and generalized epilepsy.
Zhen Sun, Jing Zhang, Yulong Li, Miao Tuo, Limin Yu, Yun Wang, Yanping Sun   +6 more
doaj   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Asynchronous suppression of visual cortex during absence seizures in stargazer mice

Nature Communications, 2018
Absence epilepsy is associated with frequent generalized spike-wave seizures and loss of awareness. Here the authors use 2-photon calcium imaging of primary visual cortex in a genetic mouse model of absence epilepsy and find that cortical neurons are ...
Jochen Meyer, Atul Maheshwari, Jeffrey Noebels, Stelios Smirnakis   +3 more
doaj   +1 more source

Does variation in NIPA2 contribute to genetic generalized epilepsy?

, 2014
Does variation in NIPA2 contribute to genetic generalized ...
Michael S Hildebrand (10688811), Susannah T Bellows (15888839), Ingrid E Scheffer (10577391), John A Damiano (10688784), Saul A Mullen (13602007), Samuel F Berkovic (10577323)   +5 more
core  

Typical Absence Seizures and Related Epilepsy Syndromes

, 2018
Typical absence (TA) seizures are brief generalized seizures of abrupt onset and termination characterized by loss of awareness with subtle motor features.
Demet KINAY
core   +1 more source