Results 101 to 110 of about 4,320,960 (307)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
AnimalsMustelids are a very diverse carnivoran group, boasting the largest number of carnivoran species today, with the most extreme ecological adaptations. Nevertheless, Neotropical Lyncodontini, one Neotropical mustelid subfamily, is one of the least studied ...
Manuel Ruiz-García +1 more
doaj +1 more source
Genetic heterogeneity in helminths — a reply
Parasitology, 1995 The previous paper in this issue Computer model of the maintenance and selection of genetic heterogeneity in polygamous helminths by Saul uses an individual-based computer simulation to explore aspects of the transmission and maintenance of genetic heterogeneity among polygamous intestinal helminths, both in the absence and in the presence of external ...
R M, Anderson, R M, May, S, Gupta
openaire +2 more sources
Cell Death and Disease, 2018 Improving early detection of colorectal cancer (CRC) is a key public health priority as adenomas and stage I cancer can be treated with minimally invasive procedures.
N. Myint +17 more
semanticscholar +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Frontiers in GeneticsFabry disease is an X-linked lysosomal storage disorder caused by pathogenic variants in GLA, in which the kidney is a principal target organ and Fabry nephropathy is a major determinant of long-term outcome.
Yanshu Xie, Jingzi Zhong
doaj +1 more source
Genetic Diversity of Bartonella henselae in Human Infection Detected with Multispacer Typing
Emerging Infectious Diseases, 2007 We applied multispacer typing (MST) by incorporating 9 variable intergenic spacers to Bartonella henselae DNA detected in lymph node biopsy specimens from 70 patients with cat-scratch disease (CSD), in cardiac valve specimens from 2 patients with ...
Wenjun Li +2 more
doaj +1 more source
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder
Translational Psychiatry, 2017 We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD).
A. Charney +44 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source