Results 111 to 120 of about 3,275,705 (300)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A latent class approach to investigating consumer demand for genetically modified staple food in a developing country: The case of GM bananas in Uganda [PDF]

genetically modified bananas, Consumers, Choice experiment, latent class model, preference heterogeneity, Science and technology, Genetic resources, Genetically engineered crops, Genetically modified crops,
Kikulwe, Enoch, Birol, Ekin, Falck-Zepeda, José, Wesseler, Justus   +3 more
core  

Workshop Report-Heterogeneity and Successful Aging Part II: Approaches to Investigate Heterogeneity in Aging Research.

Heterogeneity in aging is a fundamental biological process arising from multifactorial etiologies, including genetic, lifestyle, and socioeconomic factors.
Kuchel, George A, Sebastiani, Paola, Participants of the NIA Heterogeneity and Successful Aging Workshop, Kumar, Vivek, Hevener, Andrea L, Ruby, J Graham   +5 more
core   +1 more source

Non-genetic heterogeneity and cell fate choice in Dictyostelium discoideum

, 2011
From microbes to metazoans, it is now clear that fluctuations in the abundance of mRNA transcripts and protein molecules enable genetically identical cells to oscillate between several distinct states (Kaern 2005).
Christopher R. L. Thompson, Alex Chattwood, Thompson, Christopher R L, Chattwood, Alex   +3 more
core   +1 more source

Tumor cell heterogeneity [PDF]

, 2013
The paper deals with the analysis of literary data on the tumor cell heterogeneity. Phenotypic, genetic and epigenetic mechanisms of heterogeneity are considered. The heterogeneity or metastasis is considered too.
Sherban, S.D., Savtsova, Z.D., Chekhun, V.F.   +2 more
core   +2 more sources

A peptide puzzle

eLife, 2018
Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
Jian Guan, Nilabh Shastri
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Overcoming genetic heterogeneity in industrial fermentations

, 2019
Engineering the synthesis of massive amounts of therapeutics, enzymes or commodity chemicals can select for subpopulations of nonproducer cells, owing to metabolic burden and product toxicity. Deep DNA sequencing can be used to detect undesirable genetic
Sommer, Morten Otto Alexander, Rugbjerg, Peter, Peter Rugbjerg, Morten O. A. Sommer   +3 more
core   +1 more source

Distinguishing regional from within-codon rate heterogeneity in DNA sequence alignments [PDF]

, 2009
We present an improved phylogenetic factorial hidden Markov model (FHMM) for detecting two types of mosaic structures in DNA sequence alignments, related to (1) recombination and (2) rate heterogeneity.
Husmeier, D., Mantzaris, Alexander Vassilios, Dirk Husmeier, Mantzaris, A.V., Alexander V. Mantzaris   +4 more
core   +1 more source

Genetic heterogeneity in tuberous sclerosis

Genomics, 1990
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by widespread hamartosis. Preliminary evidence of linkage between the TSC locus and markers on chromosome 9q34 was established, but subsequently disputed. More recently, a putative TSC locus on chromosome 11 has been suggested and genetic heterogeneity seems likely.
Janssen, L. A., Sandkuyl, L. A., Merkens, E. C., Maat-Kievit, J. A., Sampson, J. R., Fleury, P., Hennekam, R. C., Grosveld, G. C., Lindhout, D., Halley, D. J.   +9 more
openaire   +3 more sources