Results 111 to 120 of about 945,528 (300)

Marital Status and Unobserved Heterogeneity - Do twins suggest a genetic inheritance? [PDF]

The purpose of this study is to reveal the importance of unobserved heterogeneity on marital status. The results for monozygotic (identical) and dizygotic twins indicate an important genetic component in marital status.
Nilsson, William
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

A peptide puzzle

eLife, 2018
Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
Jian Guan, Nilabh Shastri
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A latent class approach to investigating consumer demand for genetically modified staple food in a developing country: The case of GM bananas in Uganda [PDF]

genetically modified bananas, Consumers, Choice experiment, latent class model, preference heterogeneity, Science and technology, Genetic resources, Genetically engineered crops, Genetically modified crops,
Birol, Ekin, Falck-Zepeda, José, Kikulwe, Enoch, Wesseler, Justus   +3 more
core  

Genetic heterogeneity in tuberous sclerosis

Genomics, 1990
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by widespread hamartosis. Preliminary evidence of linkage between the TSC locus and markers on chromosome 9q34 was established, but subsequently disputed. More recently, a putative TSC locus on chromosome 11 has been suggested and genetic heterogeneity seems likely.
Janssen, L. A., Sandkuyl, L. A., Merkens, E. C., Maat-Kievit, J. A., Sampson, J. R., Fleury, P., Hennekam, R. C., Grosveld, G. C., Lindhout, D., Halley, D. J.   +9 more
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Characterizing the genetic architecture of drug response using gene-context interaction methods

Cell Genomics
Summary: Identifying factors that affect treatment response is a central objective of clinical research, yet the role of common genetic variation remains largely unknown.
Michal Sadowski, Mike Thompson, Joel Mefford, Tanushree Haldar, Akinyemi Oni-Orisan, Richard Border, Ali Pazokitoroudi, Na Cai, Julien F. Ayroles, Sriram Sankararaman, Andy W. Dahl, Noah Zaitlen   +11 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source