Results 111 to 120 of about 4,320,960 (307)

Editorial: Basic and clinical research on adult snoring and obstructive sleep apnea syndrome

Frontiers in Neurology, 2023
Yewen Shi, Xiangdong Tang, Xiangdong Tang, Tongxin Xie, Yitong Zhang, Xiaoyong Ren   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Genetic heterogeneity in tuberous sclerosis

Genomics, 1990
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by widespread hamartosis. Preliminary evidence of linkage between the TSC locus and markers on chromosome 9q34 was established, but subsequently disputed. More recently, a putative TSC locus on chromosome 11 has been suggested and genetic heterogeneity seems likely.
Janssen, L. A., Sandkuyl, L. A., Merkens, E. C., Maat-Kievit, J. A., Sampson, J. R., Fleury, P., Hennekam, R. C., Grosveld, G. C., Lindhout, D., Halley, D. J.   +9 more
openaire   +3 more sources

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Nature Medicine, 2016
Genetic heterogeneity contributes to clinical outcome and progression of most tumors, but little is known about allelic diversity for epigenetic compartments, and almost no data exist for acute myeloid leukemia (AML). We examined epigenetic heterogeneity
Sheng Li, Francine E. Garrett-Bakelman, S. Chung, M. Sanders, Todd Hricik, Franck Rapaport, Jay L. Patel, R. Dillon, P. Vijay, Anna L. Brown, A. Perl, J. Cannon, L. Bullinger, S. Luger, M. Becker, I. Lewis, L. To, R. Delwel, B. Löwenberg, H. Döhner, K. Döhner, M. Guzman, D. Hassane, G. Roboz, D. Grimwade, P. Valk, R. D’Andrea, M. Carroll, Christopher Y. Park, D. Neuberg, R. Levine, A. Melnick, C. Mason   +32 more
semanticscholar   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Genetic heterogeneity of motor neuropathies

Neurology, 2017
Objective: To study the prevalence, molecular cause, and clinical presentation of hereditary motor neuropathies in a large cohort of patients from the North of England.
B. Bánsági, H. Griffin, R. Whittaker, T. Antoniadi, T. Evangelista, J. Miller, M. Greenslade, Natalie Forester, J. Duff, Anna Bradshaw, S. Kleinle, V. Boczonadi, H. Steele, V. Ramesh, E. Frankó, A. Pyle, Hanns Lochmüller, P. Chinnery, R. Horvath   +18 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A peptide puzzle

eLife, 2018
Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
Jian Guan, Nilabh Shastri
doaj   +1 more source

Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases

Clinical Cancer Research, 2017
Purpose: Paired primary breast cancers and metachronous metastases after adjuvant treatment are reported to differ in their clonal composition and genetic alterations, but it is unclear whether these differences stem from the selective pressures of the ...
C. Ng, F. Bidard, S. Piscuoglio, F. Geyer, R. Lim, Ino de Bruijn, R. Shen, F. Pareja, Samuel H. Berman, Lu Wang, J. Pierga, A. Vincent‐Salomon, A. Viale, L. Norton, B. Sigal, B. Weigelt, P. Cottu, J. Reis-Filho   +17 more
semanticscholar   +1 more source