Genome-wide association study reveals genomic loci of sex differentiation and gonadal development in Plectropomus leopardus [PDF]
Frontiers in Genetics, 2023 Introduction:Plectropomus leopardus, a commercially significant marine fish, is primarily found in the Western Pacific regions and along the coast of Southeast Asia.
Yongbo Wang, Wang Yongbo
exaly +4 more sources
Genomic loci influence patterns of structural covariance in the human brain. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance The coordinated patterns of changes in the human brain throughout life, driven by brain development, aging, and diseases, remain largely unexplored regarding their underlying genetic determinants.
Wen J +65 more
europepmc +2 more sources
Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders. [PDF]
Psychiatry Clin NeurosciAnxiety disorders are prevalent and anxiety symptoms (ANX) co‐occur with many psychiatric disorders. We aimed to identify genomic loci associated with ANX, characterize its genetic architecture, and genetic overlap with psychiatric disorders.
Tesfaye M +17 more
europepmc +2 more sources
Genomic imprinting of two antagonistic loci [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2001 We present a model that considers the coevolution of genomic imprinting at a growth factor locus and an antagonistic growth suppressor locus. With respect to the two loci considered independently, our model makes the familiar predictions that an imprinted growth factor locus will only be expressed from the paternally derived allele and an imprinted ...
Jon F Wilkins, David Haig
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Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
Cell, 2013 SUMMARY The spatiotemporal organization and dynamics of chromatin play critical roles in regulating genome function. However, visualizing specific, endogenous genomic loci remains challenging in living cells.
Luke Gilbert, Beth Cimini
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PHYLUCE is a software package for the analysis of conserved genomic loci [PDF]
Bioinformatics, 2015 Summary Targeted enrichment of conserved and ultraconserved genomic elements allows universal collection of phylogenomic data from hundreds of species at multiple time scales (< 5 Ma to > 300 Ma).
B. Faircloth
semanticscholar +3 more sources
GLANET: genomic loci annotation and enrichment tool [PDF]
Bioinformatics, 2017 AbstractMotivationGenomic studies identify genomic loci representing genetic variations, transcription factor (TF) occupancy, or histone modification through next generation sequencing (NGS) technologies. Interpreting these loci requires evaluating them with known genomic and epigenomic annotations.ResultsWe present GLANET as a comprehensive annotation
Burçak Otlu +3 more
semanticscholar +6 more sources
Multivariate genomic scan implicates novel loci and haem metabolism in human ageing
Nature Communications, 2020 Ageing phenotypes, such as years lived in good health (healthspan), total years lived (lifespan), and survival until an exceptional old age (longevity), are of interest to us all but require exceptionally large sample sizes to study genetically.
James F Wilson +2 more
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ParSite is a multicolor DNA labeling system that allows for simultaneous imaging of triple genomic loci in living cells. [PDF]
PLoS BiologyThe organization of the human genome in space and time is critical for transcriptional regulation and cell fate determination. However, robust methods for tracking genome organization or genomic interactions over time in living cells are lacking.
Xiaohui He, Yadong Sun, Hanhui Ma
doaj +2 more sources
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Cell, 2019 Summary Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear.
Glyn Lewis +2 more
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