Results 41 to 50 of about 1,069,336 (306)

Management of pediatric keratoconus - Evolving role of corneal collagen cross-linking: An update

open access: yesIndian Journal of Ophthalmology, 2013
Pediatric keratoconus demonstrates several distinctive management issues in comparison with adult keratoconus with respect to under-diagnosis, poor compliance and modifications in treatment patterns.
Vardhaman P Kankariya   +3 more
doaj   +1 more source

Accuracy of multi-trait genomic selection using different methods [PDF]

open access: yes, 2011
Background Genomic selection has become a very important tool in animal genetics and is rapidly emerging in plant genetics. It holds the promise to be particularly beneficial to select for traits that are difficult or expensive to measure, such as traits
Veerkamp Roel F   +5 more
core   +1 more source

Keratoconus: A biomechanical perspective on loss of corneal stiffness

open access: yesIndian Journal of Ophthalmology, 2013
Keratoconus (KC) is progressive disease of corneal thinning, steepening and collagen degradation. Biomechanics of the cornea is maintained by the intricate collagen network, which is responsible for its unique shape and function.
Abhijit Sinha Roy   +2 more
doaj   +1 more source

Genomic risk loci from the multivariate GWAS of psycho-cardiometabolic multimorbidity.

open access: yes, 2023
Genomic risk loci from the multivariate GWAS of psycho-cardiometabolic multimorbidity.
Marjo-Riitta Järvelin (2141947)   +9 more
core   +1 more source

Intrastromal corneal ring segments for management of keratoconus

open access: yesIndian Journal of Ophthalmology, 2013
Keratoconus is a progressive corneal ectasia, which can be managed both by conservative measures like glasses or contact lenses in non-progressive cases or surgical procedures like collagen crosslinking (CXL) with or without adjuvant measures like ...
Sri Ganesh   +4 more
doaj   +1 more source

Prioritization of Copy Number Variation Loci Associated with Autism from AutDB-An Integrative Multi-Study Genetic Database. [PDF]

open access: yesPLoS ONE, 2013
Copy number variants (CNVs) are thought to play an important role in the predisposition to autism spectrum disorder (ASD). However, their relatively low frequency and widespread genomic distribution complicates their accurate characterization and ...
Idan Menashe   +2 more
doaj   +1 more source

Genomic loci susceptible to systematic sequencing bias in clinical whole genomes [PDF]

open access: yesGenome Research, 2019
Abstract Accurate massively parallel sequencing (MPS) of genetic variants is key to many areas of science and medicine, such as cataloguing population genetic variation and diagnosing genetic diseases. Certain genomic positions can be prone to higher rates of systematic sequencing and alignment bias that limit accuracy, resulting in ...
Freeman, TM   +57 more
openaire   +5 more sources

Hundreds of variants clustered in genomic loci and biological pathways affect human height [PDF]

open access: yes, 2010
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1)
Lawrence, Robert W   +999 more
core   +1 more source

Collagen cross linking: Current perspectives

open access: yesIndian Journal of Ophthalmology, 2013
Keratoconus is a common ectatic disorder occurring in more than 1 in 1,000 individuals. The condition typically starts in adolescence and early adulthood. It is a disease with an uncertain cause and its progression is unpredictable, but in extreme cases,
Srinivas K Rao
doaj   +1 more source

NRE: a tool for exploring neutral loci in the human genome [PDF]

open access: yesBMC Bioinformatics, 2012
Abstract Background Analyzing regions of the genome where genetic variation is free from the confounding effects of natural selection is essential for many population genetic studies. Several recent studies in humans have stressed the large effect of natural selection at linked neutral sites and have shown that the ...
Arbiza Leonardo   +2 more
openaire   +3 more sources

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