Results 21 to 30 of about 1,321,379 (303)
Mapping of promoter usage QTL using RNA-seq data reveals their contributions to complex traits.
PLoS Computational Biology, 2022 Genomic variations are associated with gene expression levels, which are called expression quantitative trait loci (eQTL). Most eQTL may affect the total gene expression levels by regulating transcriptional activities of a specific promoter. However, the
Naoto Kubota, Mikita Suyama
doaj +1 more source
Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
medRxiv, 2020 Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a heritability of 60-80%, much of which is attributable to common risk alleles, suggesting genome-wide association studies can inform our understanding of aetiology.
S. Ripke, J. Walters, M. O’Donovan
semanticscholar +1 more source
Comparative genomics of vertebrate Fox cluster loci [PDF]
BMC Genomics, 2006 Vertebrate genomes contain numerous duplicate genes, many of which are organised into paralagous regions indicating duplication of linked groups of genes. Comparison of genomic organisation in different lineages can often allow the evolutionary history of such regions to be traced.
Wotton, KR, Shimeld, SM
openaire +5 more sources
BMC Bioinformatics, 2017 Background Genomic interaction studies use next-generation sequencing (NGS) to examine the interactions between two loci on the genome, with subsequent bioinformatics analyses typically including annotation, intersection, and merging of data from ...
William W. Greenwald +5 more
doaj +1 more source
Prevalence of small base-pairing RNAs derived from diverse genomic loci
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, 2020 Small RNAs (sRNAs) that act by base-pairing have been shown to play important roles in fine-tuning the levels and translation of their target transcripts across a variety of model and pathogenic organisms.
Philip P. Adams, G. Storz
semanticscholar +1 more source
Evolutionary Genomics of Immunoglobulin-Encoding Loci in Vertebrates [PDF]
Current Genomics, 2012 Immunoglobulins (or antibodies) are an essential element of the jawed vertebrate adaptive immune response system. These molecules have evolved over the past 500 million years and generated highly specialized proteins that recognize an extraordinarily large number of diverse substances, collectively known as antigens.
Das, Sabyasachi +4 more
openaire +2 more sources
Applications in Plant Sciences, 2020 Premise Putatively single‐copy nuclear (SCN) loci, which are identified using genomic resources of closely related species, are ideal for phylogenomic inference.
Johanna R. Jantzen +7 more
doaj +1 more source
Genome-wide significant loci for addiction and anxiety [PDF]
European Psychiatry, 2016 AbstractBackgroundPsychiatric comorbidity is common among individuals with addictive disorders, with patients frequently suffering from anxiety disorders. While the genetic architecture of comorbid addictive and anxiety disorders remains unclear, elucidating the genes involved could provide important insights into the underlying etiology.MethodsHere we
K, Hodgson +13 more
openaire +2 more sources
Deep anterior lamellar keratoplasty in the management of keratoconus
Indian Journal of Ophthalmology, 2013 Advanced cases of keratoconus often require surgical intervention to restore corneal anatomy and improve eyesight. Penetrating keratoplasty (PK) although commonly performed has potential risk of immunological rejection and is now no longer automatically ...
Rajesh Fogla
doaj +1 more source
Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence
Nature Communications, 2020 The phenotypic correlation between human intelligence and brain volume (BV) is considerable (r ≈ 0.40), and has been shown to be due to shared genetic factors.
P. Jansen +8 more
semanticscholar +1 more source