Results 1 to 10 of about 4,357,979 (209)

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Nature Communications, 2021
Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell ...
Aleksandra Lezaja, Andreas Panagopoulos, Yanlin Wen, Edison Carvalho, Ralph Imhof, Matthias Altmeyer   +5 more
doaj   +1 more source

Dissecting the roles of MBD2 isoforms and domains in regulating NuRD complex function during cellular differentiation

Nature Communications, 2023
The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of ...
Nina Schmolka, Ino D. Karemaker, Richard Cardoso da Silva, Davide C. Recchia, Vincent Spegg, Jahnavi Bhaskaran, Michael Teske, Nathalie P. de Wagenaar, Matthias Altmeyer, Tuncay Baubec   +9 more
doaj   +1 more source

Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains

Nature Communications, 2022
Mapping nucleolar-associated domains (NADs) is challenging as the nucleolus is membrane-less. Here the authors adapted the DNA adenine methyltransferase identification (DamID) method by engineering a “nucleolar histone” that can mark genomic contacts ...
Cristiana Bersaglieri, Jelena Kresoja-Rakic, Shivani Gupta, Dominik Bär, Rostyslav Kuzyakiv, Martina Panatta, Raffaella Santoro   +6 more
doaj   +1 more source

Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses

Cell Discovery, 2021
Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself.
Flurina Boehi, Patrick Manetsch, Michael O. Hottiger   +2 more
doaj   +1 more source

Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Cell Death and Disease, 2022
Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of receptor tyrosine kinase ErbB-2/HER2.
Santiago Madera, Franco Izzo, María F. Chervo, Agustina Dupont, Violeta A. Chiauzzi, Sofia Bruni, Ezequiel Petrillo, Sharon S. Merin, Mara De Martino, Diego Montero, Claudio Levit, Gabriel Lebersztein, Fabiana Anfuso, Agustina Roldán Deamicis, María F. Mercogliano, Cecilia J. Proietti, Roxana Schillaci, Patricia V. Elizalde, Rosalía I. Cordo Russo   +18 more
doaj   +1 more source

HSL1 and BAM1/2 impact epidermal cell development by sensing distinct signaling peptides

Nature Communications, 2022
HAESA and HSL2 are receptors for IDA/IDL-family signaling peptides in plants. Here the authors show that HSL1, previously shown to recognize CLE9, preferentially binds IDA/IDL peptides and regulates leaf epidermal patterning independently of CLE peptides.
Andra-Octavia Roman, Pedro Jimenez-Sandoval, Sebastian Augustin, Caroline Broyart, Ludwig A. Hothorn, Julia Santiago   +5 more
doaj   +1 more source

New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System

Biology, 2021
Vav proteins act as tyrosine phosphorylation-regulated guanosine nucleotide exchange factors for Rho GTPases and as molecular scaffolds. In mammals, this family of signaling proteins is composed of three members (Vav1, Vav2, Vav3) that work downstream of
Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Salvatore Fabbiano, Mauricio Menacho-Márquez, Vincent Sauzeau, Mercedes Dosil, Xosé R. Bustelo   +6 more
doaj   +1 more source

Molecular mechanisms of neural crest formation [PDF]

, 1999
The neural crest is a transient population of multipotent precursor cells named for its site of origin at the crest of the closing neural folds in vertebrate embryos.
Bronner-Fraser, Marianne, LaBonne, Carole   +1 more
core   +1 more source

In silico analysis of prognostic and diagnostic significance of target genes from prostate cancer cell lines derived exomicroRNAs

Cancer Cell International, 2023
Background Cancer-secreted exovesicles are important for cell-to-cell communication by altering cancer-related signalling pathways. Exovesicles-derived miRNAs (exomiRNAs)-target genes can be useful for diagnostic and prognostic purposes. Methods ExomiRNA
Antonio Altuna-Coy, Xavier Ruiz-Plazas, Verónica Arreaza-Gil, José Segarra-Tomás, Matilde R. Chacón   +4 more
doaj   +1 more source

Molecular Mechanisms [PDF]

, 2017
Ectoine, a compatible solute and osmolyte, is known to be an effective protectant of biomolecules and whole cells against heating, freezing and extreme salinity.
Hahn, Marc Benjamin, Kunte, Hans-Jörg, Meyer, Susann, Schröter, Maria-Astrid, Solomun, Tihomir, Sturm, Heinz   +5 more
core   +1 more source