Results 41 to 50 of about 2,439,565 (268)

Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight

Cells, 2021
Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids.
Ann-Katrin Hopp, Michael O. Hottiger
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Lentinula edodes Cultured Extract Intake at Puberty Mitigates Inflammatory Signals at the Mammary Glands by the Involvement of Epigenetic Mechanisms in BALB/c Mice

The Breast Journal
Exposure to immune stress or lipopolysaccharide (LPS) during critical developmental stages like puberty may lead to gut microbiome dysbiosis and epigenetic dysregulation in mammary glands, affecting gene expression and potentially elevating breast cancer
Hamed Yasavoli-Sharahi, Roghayeh Shahbazi, Nawal Alsadi, Nasim Bondar Sahebi, Cyrille Cuenin, Vincent Cahais, Felicia Fei-Lei Chung, Zdenko Herceg, Chantal Matar   +8 more
doaj   +1 more source

Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

Cell Reports
Summary: Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53, forms DNA damage-associated condensates, and has been implicated in p53 activation ...
Antonio Galarreta, Virginia Pasti, Julia Vornberger, Ralph Imhof, Mariano Oppikofer, Matthias Altmeyer   +5 more
doaj   +1 more source

Molecular mechanisms of lidocaine

Annals of Medicine & Surgery, 2021
Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations. Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory, and antithrombotic effects. Lidocaine exerts these effects under both acute and chronic pain conditions and acute respiratory distress syndrome through mechanisms that can ...
Karnina, Resiana, Arif, Syafri Kamsul, Hatta, Mochammad, Bukhari, Agussalim   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency

EMBO Reports
Pluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, their gene expression signature only partially resembles that of developmental ground-state. Induced PRAMEL7
Meneka Rupasinghe, Cristiana Bersaglieri, Deena M Leslie Pedrioli, Patrick GA Pedrioli, Martina Panatta, Michael O Hottiger, Paolo Cinelli, Raffaella Santoro   +7 more
doaj   +1 more source

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

Nature Communications, 2016
Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides ...
Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga   +11 more
doaj   +1 more source

Erratum: Hopp, A.K., et al. Regulation of Glucose Metabolism by NAD⁺ and ADP-Ribosylation. Cells 2019, 8, 890

Cells, 2019
Change in References list order. [...]
Ann-Katrin Hopp, Patrick Grüter, Michael O. Hottiger   +2 more
doaj   +1 more source

Molecular mechanisms of thermosensation

Folia Pharmacologica Japonica, 2004
We feel a wide range of temperatures spanning from cold to heat. Within this range, temperatures over about 43 degrees C and below about 15 degrees C evoke not only a thermal sensation, but also a feeling of pain. In mammals, six thermosensitive ion channels have been reported, all of which belong to the TRP (transient receptor potential) super family.
openaire   +3 more sources