Results 61 to 70 of about 4,358,128 (358)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency

EMBO Reports
Pluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, their gene expression signature only partially resembles that of developmental ground-state. Induced PRAMEL7
Meneka Rupasinghe, Cristiana Bersaglieri, Deena M Leslie Pedrioli, Patrick GA Pedrioli, Martina Panatta, Michael O Hottiger, Paolo Cinelli, Raffaella Santoro   +7 more
doaj   +1 more source

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

Nature Communications, 2016
Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides ...
Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga   +11 more
doaj   +1 more source

Erratum: Hopp, A.K., et al. Regulation of Glucose Metabolism by NAD⁺ and ADP-Ribosylation. Cells 2019, 8, 890

Cells, 2019
Change in References list order. [...]
Ann-Katrin Hopp, Patrick Grüter, Michael O. Hottiger   +2 more
doaj   +1 more source

Polar Molecular Organisation in Liquid Crystals [PDF]

, 2003
Various possibilities of polar self-organisation in low molar mass nematic, smectic and columnar liquid crystals are discussed with particular focus on the underlying molecular symmetries and interactions.
Photinos, D. J., Vanakaras, A. G.
core   +1 more source

Molecular mechanisms of thermosensation

Folia Pharmacologica Japonica, 2004
We feel a wide range of temperatures spanning from cold to heat. Within this range, temperatures over about 43 degrees C and below about 15 degrees C evoke not only a thermal sensation, but also a feeling of pain. In mammals, six thermosensitive ion channels have been reported, all of which belong to the TRP (transient receptor potential) super family.
openaire   +3 more sources

Molecular mechanisms of atopy [PDF]

Mediators of Inflammation, 2001
Production of specific immunoglobulin (Ig)E is the characteristic abnormality of atopy. IgE is produced by B lymphocytes under the influence of interleukin (IL)4 and IL-13. IgE binds to high-affinity IgE receptors (Fc«RI) on mast cells to induce degranulation and mediator synthesis.
openaire   +3 more sources

Molecular Mechanisms of Hepatotoxicity

International Journal of Molecular Sciences, 2023
Drug-induced liver injury, also known as drug-induced hepatotoxicity (DILI), is a major cause of medicine withdrawal (prescription or over-the-counter) from the market [...]
Antonietta Messina, Jean-Charles Duclos-Vallée   +1 more
openaire   +2 more sources

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

The epigenetic circle: feedback loops in the maintenance of cellular memory

Epigenetics & Chromatin
The memory of gene expression states, active or repressive, is a fundamental biological concept as it controls cell fate in development, immunity and abiotic stress responses.
Marko Tomljanović, Cita Hanif Muflihah, Dejan Rajkovski, Pawel Mikulski   +3 more
doaj   +1 more source