Results 61 to 70 of about 6,482,931 (261)
Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling
Cell ReportsSummary: Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53, forms DNA damage-associated condensates, and has been implicated in p53 activation ...
Antonio Galarreta +5 more
doaj +1 more source
Invasion Mechanisms of Bladder Cancer: A Molecular Review
, 2016 Bladder cancer (BC) is a very common cancer and it has high mortality rates, especially in late stages. BC is considered as a different disease in various stages and grades. Non-muscle-invasive BC and muscle-invasive BC have different properties.
Kamil Fehmi Narter, Kubilay Sabuncu
core +1 more source
Molecular Mechanisms of Eosinophilic Esophagitis
, 2021 Food hypersensitivity is a group of diseases arising from a specific immune response that reproduces on exposure to a given food. The current understanding of molecular mechanisms and immunopathology of non-IgE-mediated/mixed food hypersensitivity, e.g.,
Sonya O. Vysochanskaya +6 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular mechanisms of thermosensation
Folia Pharmacologica Japonica, 2004 We feel a wide range of temperatures spanning from cold to heat. Within this range, temperatures over about 43 degrees C and below about 15 degrees C evoke not only a thermal sensation, but also a feeling of pain. In mammals, six thermosensitive ion channels have been reported, all of which belong to the TRP (transient receptor potential) super family.
openaire +3 more sources
PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
EMBO ReportsPluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, their gene expression signature only partially resembles that of developmental ground-state. Induced PRAMEL7
Meneka Rupasinghe +7 more
doaj +1 more source
Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
Nature Communications, 2016 Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides ...
Emmanuele Crespan +11 more
doaj +1 more source
Hepatotoxicity : molecular mechanisms and pathophysiology
, 2019 The current Special Issue is devoted to the broad spectrum of hepatotoxicity with its molecular mechanisms and pathophysiology, presented in eight publications. Scientists were from various countries, including the US, Mexico, the Czech Republic, Germany,
Rolf Teschke, Teschke, Rolf
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source