Results 81 to 90 of about 6,482,931 (261)

Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model

Molecular Oncology, 2022
Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall‐cell lung cancer (NSCLC).
Javier Robles‐Valero, Lucía Fernández‐Nevado, Myriam Cuadrado, Luis Francisco Lorenzo‐Martín, Isabel Fernández‐Pisonero, Antonio Abad, Esther Redín, Luis Montuenga, Dionisio Martín‐Zanca, Anna Bigas, Moisés Mallo, Mercedes Dosil, Xosé R. Bustelo   +12 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

COVID-19: Ivermectin; Molecular Mechanisms, Limitations, Suggestions

, 2020
To date, no effective treatment has been found against coronaviruses (CoVs), which have re-emerged with severe acute respiratory syndrome CoV-2 (SARS-CoV-2) and have a high potential for disease in humans as well as domestic and wild animal species.
Ceren ANLAŞ, Güler, Eray Metin, Eray Metin GÜLER, Bakırel, Tülay, Anlaş, Fatma Ceren, Kesmen, Mustafa, Tülay BAKIREL, Mustafa KESMEN   +7 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Photocarcinogenesis – Molecular Mechanisms

Collegium antropologicum, 2007
The carcinogenicity (photocarcinogenicity) of sunlight to human skin has been recognized more than a century ago. Last decades numerous experimental studies show that UV rays damage DNA, cause gene mutations leading to the development of malignant tumors such basal cell carcinomas, squamous cell carcinomas and melanomas.
Gruber, Franjo, Zamolo, Gordana, Kaštelan, Marija, Prpić Massari, Larisa, Čabrijan, Leo, Peharda, Vesna, Batinac, Tanja   +6 more
openaire   +6 more sources

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

Cell Reports, 2020
Summary: PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in homology-directed repair (HDR) is not well understood. Here, we identify the
Marco Gatti, Ralph Imhof, Qingyao Huang, Michael Baudis, Matthias Altmeyer   +4 more
doaj   +1 more source

Cancer Resistance to Immunotherapy: Molecular Mechanisms and Tackling Strategies

, 2022
Cancer immunotherapy has fundamentally altered cancer treatment; however, its efficacy is limited to a subset of patients in most clinical settings. The immune system plays a key role in cancer progression from tumor initiation to the metastatic state ...
Son Hai Vu, Jongmin Kim, Vu, Son Hai, Lee, Myeong-Sok, Preethi Vetrivel, Vetrivel, Preethi, Kim, Jongmin, Myeong-Sok Lee   +7 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene

Journal of Translational Medicine
Background From the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic adipose tissue (PPAT).
Silvia Sánchez-Martin, Antonio Altuna-Coy, Verónica Arreaza-Gil, Xana Bernal-Escoté, Joan Francesc Garcia Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas, Matilde R. Chacón   +8 more
doaj   +1 more source

New Molecular Mechanisms and Markers in Inflammatory Disorders, 2nd Edition

This article belongs to the Special Issue “New Molecular Mechanisms and Markers in Inflammatory Disorders, 2nd Edition” [...
Elena Vianello, Emanuela Rita Galliera
core   +1 more source