Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin
Cell Reports, 2017 The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection.
Stefania Pellegrino +4 more
doaj +1 more source
RNA assay identifies a previous misclassification of BARD1 c.1977A>G variant
Scientific Reports, 2021 Case–control studies have shown an association of BARD1 with hereditary breast and/or ovarian cancer (HBOC) predisposition. BARD1 alternatively spliced isoforms are abundant and some are highly expressed in different cancer types.
Paula Rofes +10 more
doaj +1 more source
Mechanisms of two-color laser-induced field-free molecular orientation [PDF]
, 2012 Two mechanisms of two-color (\omega + 2\omega) laser-induced field-free molecular orientation, based on the hyperpolarizability and ionization depletion, are explored and compared. The CO molecule is used as a computational example.
Eugene Frumker +9 more
core +2 more sources
Molecular mechanism of preconditioning [PDF]
IUBMB Life, 2008 AbstractDuring the last 20 years, since the appearance of the first publication on ischemic preconditioning (PC), our knowledge of this phenomenon has increased exponentially. PC is defined as an increased tolerance to ischemia and reperfusion induced by previous sublethal period ischemia.
Manika, Das, Dipak K, Das
openaire +2 more sources
Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study [PDF]
, 2013 Circular Dichroism (CD) spectroscopy is a powerful method for investigating conformational changes in proteins and therefore has numerous applications in structural and molecular biology. Here a computational investigation of the CD spectrum of the Human
A Roy +42 more
core +3 more sources
Molecular mechanisms of fibrinolysis [PDF]
British Journal of Haematology, 2005 SummaryThe molecular mechanisms that finely co‐ordinate fibrin formation and fibrinolysis are now well defined. The structure and function of all major fibrinolytic proteins, which include serine proteases, their inhibitors, activators and receptors, have been characterized.
Gabriela, Cesarman-Maus +1 more
openaire +2 more sources
Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Nature Communications, 2022 S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and ...
Elizaveta Lyapina +30 more
doaj +1 more source
Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]
, 2019 The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe +1 more
core +2 more sources
Ultrafast Molecular Imaging by Laser Induced Electron Diffraction [PDF]
, 2011 We address the feasibility of imaging geometric and orbital structure of a polyatomic molecule on an attosecond time-scale using the laser induced electron diffraction (LIED) technique.
A. Keller +7 more
core +4 more sources
Author Correction: Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs
Scientific Data, 2020 A Correction to this paper has been published: https://doi.org/10.1038/s41597-020-00759 ...
Egor Marin +12 more
doaj +1 more source