Results 21 to 30 of about 2,439,565 (268)

Molecular mechanisms of fibrinolysis [PDF]

British Journal of Haematology, 2005
SummaryThe molecular mechanisms that finely co‐ordinate fibrin formation and fibrinolysis are now well defined. The structure and function of all major fibrinolytic proteins, which include serine proteases, their inhibitors, activators and receptors, have been characterized.
Gabriela, Cesarman-Maus, Katherine A, Hajjar   +1 more
openaire   +2 more sources

Photocarcinogenesis--molecular mechanisms.

Collegium antropologicum, 2007
The carcinogenicity (photocarcinogenicity) of sunlight to human skin has been recognized more than a century ago. Last decades numerous experimental studies show that UV rays damage DNA, cause gene mutations leading to the development of malignant tumors such basal cell carcinomas, squamous cell carcinomas and melanomas.
Gruber, Franjo, Zamolo, Gordana, Kaštelan, Marija, Prpić Massari, Larisa, Čabrijan, Leo, Peharda, Vesna, Batinac, Tanja   +6 more
openaire   +6 more sources

Author Correction: Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs

Scientific Data, 2020
A Correction to this paper has been published: https://doi.org/10.1038/s41597-020-00759 ...
Egor Marin, Aleksandra Luginina, Anastasiia Gusach, Kirill Kovalev, Sergey Bukhdruker, Polina Khorn, Vitaly Polovinkin, Elizaveta Lyapina, Andrey Rogachev, Valentin Gordeliy, Alexey Mishin, Vadim Cherezov, Valentin Borshchevskiy   +12 more
doaj   +1 more source

Mirror proteorhodopsins

Communications Chemistry, 2023
Proteorhodopsins (PRs), bacterial light-driven outward proton pumps comprise the first discovered and largest family of rhodopsins, they play a significant role in life on the Earth.
Ivan S. Okhrimenko, Kirill Kovalev, Lada E. Petrovskaya, Nikolay S. Ilyinsky, Alexey A. Alekseev, Egor Marin, Tatyana I. Rokitskaya, Yuri N. Antonenko, Sergey A. Siletsky, Petr A. Popov, Yuliya A. Zagryadskaya, Dmytro V. Soloviov, Igor V. Chizhov, Dmitrii V. Zabelskii, Yury L. Ryzhykau, Alexey V. Vlasov, Alexander I. Kuklin, Andrey O. Bogorodskiy, Anatolii E. Mikhailov, Daniil V. Sidorov, Siarhei Bukhalovich, Fedor Tsybrov, Sergey Bukhdruker, Anastasiia D. Vlasova, Valentin I. Borshchevskiy, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Ernst Bamberg, Valentin I. Gordeliy   +28 more
doaj   +1 more source

A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity

Emerging Microbes and Infections, 2021
African swine fever virus (ASFV) is the causal agent of a fatal disease of domestic swine for which no effective antiviral drugs are available. Recently, it has been shown that microtubule-targeting agents hamper the infection cycle of different viruses.
Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan, Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre Serobian, Marco Neves, João Ferreira, Fernando Ferreira, Hovakim Zakaryan   +19 more
doaj   +1 more source

Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism

Journal of Experimental & Clinical Cancer Research, 2019
Background Thyroid carcinoma includes several variants characterized by different biological and clinical features: from indolent microcarcinoma to undifferentiated and aggressive anaplastic carcinoma. Inflammation plays a critical role in thyroid tumors.
Mara Mazzoni, Giuseppe Mauro, Marco Erreni, Paola Romeo, Emanuela Minna, Maria Grazia Vizioli, Cristina Belgiovine, Maria Grazia Rizzetti, Sonia Pagliardini, Roberta Avigni, Maria Chiara Anania, Paola Allavena, Maria Grazia Borrello, Angela Greco   +13 more
doaj   +1 more source

Molecular model of a sensor of two-component signaling system

Scientific Reports, 2021
Two-component systems (TCS) are widespread signaling systems present in all domains of life. TCS typically consist of a signal receptor/transducer and a response regulator.
Yury L. Ryzhykau, Philipp S. Orekhov, Maksim I. Rulev, Alexey V. Vlasov, Igor A. Melnikov, Dmytro A. Volkov, Mikhail Yu. Nikolaev, Dmitrii V. Zabelskii, Tatiana N. Murugova, Vladimir V. Chupin, Andrey V. Rogachev, Andrey Yu. Gruzinov, Dmitri I. Svergun, Martha E. Brennich, Ivan Yu. Gushchin, Montserrat Soler-Lopez, Arne Bothe, Georg Büldt, Gordon Leonard, Martin Engelhard, Alexander I. Kuklin, Valentin I. Gordeliy   +21 more
doaj   +1 more source

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Cells, 2021
Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal system for protecting cells and the whole body from various types of stress.
Olga G. Zatsepina, Michael B. Evgen’ev, David G. Garbuz   +2 more
doaj   +1 more source

Molecular mechanisms of parturition

Infectious Diseases in Obstetrics and Gynecology, 1997
The initial signal for triggering human parturition might be fetal but of trophoblastic origin. Concomitantly, this placental signal would have as its target not only the uterus but also the fetus by activating its hypothalamo-pituitary-adrenocortical axis.
openaire   +2 more sources

Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells

Cells, 2019
Colorectal cancer (CRC), the second most common cause of cancer mortality in the Western world, is a highly heterogeneous disease that is driven by a rare subpopulation of tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells ...
Pit Ullmann, Martin Nurmik, Rubens Begaj, Serge Haan, Elisabeth Letellier   +4 more
doaj   +1 more source