Results 21 to 30 of about 6,482,931 (261)
Molecular mechanisms of luteinization [PDF]
Obstetrics & Gynecology Science, 2014 Dynamic changes in steroidogenesis occur in ovarian granulosa cells during ovulation after the LH surge. The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid down-regulation of aromatase (Cyp19a1) in granulosa cells undergoing luteinization during ovulation.
openaire +2 more sources
Molecular Mechanisms of Preeclampsia [PDF]
Journal of Pregnancy, 2012 Preeclampsia is one of the leading causes of maternal morbidity/mortality. The pathogenesis of preeclampsia is still under investigation. The aim of this paper is to present the molecular mechanisms implicating in the pathway leading to preeclampsia.
N. Vitoratos, D. Hassiakos, C. Iavazzo
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Nature Communications, 2018 Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to study ...
Jone Michelena +5 more
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Molecular mechanisms of lidocaine
Annals of Medicine & Surgery, 2021 Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations. Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory, and antithrombotic effects. Lidocaine exerts these effects under both acute and chronic pain conditions and acute respiratory distress syndrome through mechanisms that can ...
Karnina, Resiana +3 more
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Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin
Cell Reports, 2017 The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection.
Stefania Pellegrino +4 more
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Epigenetics & Chromatin, 2023 Background Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in different nuclear functions.
Eva Monte-Serrano +5 more
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Molecular Mechanisms of Shigella Pathogenesis; Recent Advances
, 2023 Shigella species are the main cause of bacillary diarrhoea or shigellosis in humans. These organisms are the inhabitants of the human intestinal tract; however, they are one of the main concerns in public health in both developed and developing countries.
Wolfram Manuel Brück +7 more
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Pituitary Apoplexy: Risk Factors and Underlying Molecular Mechanisms [PDF]
, 2022 Pituitary apoplexy is a rare syndrome, graded from asymptomatic subclinical apoplexy to a life-threatening condition due to pituitary ischemia or haemorrhage of an enlarged pituitary gland. The risk factors and the molecular underlying mechanisms are yet
Biagetti Biagetti, Betina +5 more
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RNA assay identifies a previous misclassification of BARD1 c.1977A>G variant
Scientific Reports, 2021 Case–control studies have shown an association of BARD1 with hereditary breast and/or ovarian cancer (HBOC) predisposition. BARD1 alternatively spliced isoforms are abundant and some are highly expressed in different cancer types.
Paula Rofes +10 more
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Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Nature Communications, 2022 S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and ...
Elizaveta Lyapina +30 more
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