Results 11 to 20 of about 2,439,565 (268)
Current Pharmaceutical Design, 2014 Molecular Mechanics (MM) force fields are the methods of choice for protein simulations, which are essential in the study of conformational flexibility. Given the importance of protein flexibility in drug binding, MM is involved in most if not all Computational Structure-Based Drug Discovery (CSBDD) projects.
Vanommeslaeghe, Kenno +2 more
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Molecular Mechanisms of Preeclampsia [PDF]
Journal of Pregnancy, 2012 Preeclampsia is one of the leading causes of maternal morbidity/mortality. The pathogenesis of preeclampsia is still under investigation. The aim of this paper is to present the molecular mechanisms implicating in the pathway leading to preeclampsia.
N. Vitoratos, D. Hassiakos, C. Iavazzo
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Molecular mechanisms of etoposide
EXCLI journal, 2015 EXCLI Journal ; Vol.
Montecucco A, Zanetta F, Biamonti G
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Molecular mechanisms of luteinization [PDF]
Obstetrics & Gynecology Science, 2014 Dynamic changes in steroidogenesis occur in ovarian granulosa cells during ovulation after the LH surge. The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid down-regulation of aromatase (Cyp19a1) in granulosa cells undergoing luteinization during ovulation.
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Nature Communications, 2018 Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to study ...
Jone Michelena +5 more
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Epigenetics & Chromatin, 2023 Background Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in different nuclear functions.
Eva Monte-Serrano +5 more
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Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin
Cell Reports, 2017 The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by limiting DNA end resection.
Stefania Pellegrino +4 more
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RNA assay identifies a previous misclassification of BARD1 c.1977A>G variant
Scientific Reports, 2021 Case–control studies have shown an association of BARD1 with hereditary breast and/or ovarian cancer (HBOC) predisposition. BARD1 alternatively spliced isoforms are abundant and some are highly expressed in different cancer types.
Paula Rofes +10 more
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Molecular mechanism of preconditioning [PDF]
IUBMB Life, 2008 AbstractDuring the last 20 years, since the appearance of the first publication on ischemic preconditioning (PC), our knowledge of this phenomenon has increased exponentially. PC is defined as an increased tolerance to ischemia and reperfusion induced by previous sublethal period ischemia.
Manika, Das, Dipak K, Das
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Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
Nature Communications, 2022 S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and ...
Elizaveta Lyapina +30 more
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