Results 11 to 20 of about 4,358,128 (358)
Current Pharmaceutical Design, 2014 Molecular Mechanics (MM) force fields are the methods of choice for protein simulations, which are essential in the study of conformational flexibility. Given the importance of protein flexibility in drug binding, MM is involved in most if not all Computational Structure-Based Drug Discovery (CSBDD) projects.
Vanommeslaeghe, Kenno +2 more
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Molecular Mechanisms of Preeclampsia [PDF]
Journal of Pregnancy, 2012 Preeclampsia is one of the leading causes of maternal morbidity/mortality. The pathogenesis of preeclampsia is still under investigation. The aim of this paper is to present the molecular mechanisms implicating in the pathway leading to preeclampsia.
N. Vitoratos, D. Hassiakos, C. Iavazzo
openaire +3 more sources
Molecular mechanisms of etoposide
EXCLI journal, 2015 EXCLI Journal ; Vol.
Montecucco A, Zanetta F, Biamonti G
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Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells
Life Science Alliance, 2021 This study demonstrates how single cell normalization to genome size provides insight into genome function, here in the context of DNA double-strand break repair by 53BP1 versus BRCA1–BARD1.
Jone Michelena +3 more
doaj +1 more source
Molecular mechanisms of luteinization [PDF]
Obstetrics & Gynecology Science, 2014 Dynamic changes in steroidogenesis occur in ovarian granulosa cells during ovulation after the LH surge. The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid down-regulation of aromatase (Cyp19a1) in granulosa cells undergoing luteinization during ovulation.
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Nature Communications, 2022 While cutaneous melanoma is linked to UV radiation, acral melanoma is not. Epigenetic mechanisms function as sensors to exposures and determinants of cell identity.
Anna Luiza Silva Almeida Vicente +12 more
doaj +1 more source
Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? [PDF]
, 2017 No abstract ...
Kennedy, Simon, Salt, Ian P.
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Nature Communications, 2018 Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to study ...
Jone Michelena +5 more
doaj +1 more source
Epigenetics & Chromatin, 2023 Background Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in different nuclear functions.
Eva Monte-Serrano +5 more
doaj +1 more source
From lab to field : yield stability and shade avoidance genes are massively differentially expressed in the field [PDF]
, 2020 To unravel molecular mechanisms with the ultimate goal to achieve improved stress resilience or increased yield, plants are often studied under highly controlled conditions in which stresses are applied and in which growth‐ or architecture‐related traits
De Block, Jolien +6 more
core +2 more sources