Results 31 to 40 of about 1,321,379 (303)

Genome Scan for Blood Pressure Loci in Mice [PDF]

open access: yesHypertension, 1999
Abstract —Hypertension is a complex trait of unknown cause in humans. Mice of the inbred strain BPH/2 serve as a rodent model of human hypertension and display elevated blood pressure compared with the hypotensive strain BPL/1. An F2 intercross of BPH/2 and BPL/1 and 2 backcrosses of BPL/1 with Mus spretus
F A, Wright   +7 more
openaire   +2 more sources

Review of current indications for combined very high fluence collagen cross-linking and laser in situ keratomileusis surgery

open access: yesIndian Journal of Ophthalmology, 2013
In this brief review we will discuss the reasoning and evolution of our current use of combined very high-fluence collagen crosslinking and laser in situ keratomileusis.
Anastasios John Kanellopoulos   +1 more
doaj   +1 more source

Persisting viral sequences shape microbial CRISPR-based immunity. [PDF]

open access: yesPLoS Computational Biology, 2012
Well-studied innate immune systems exist throughout bacteria and archaea, but a more recently discovered genomic locus may offer prokaryotes surprising immunological adaptability.
Ariel D Weinberger   +9 more
doaj   +1 more source

CRISPR-mediated multiplexed live cell imaging of nonrepetitive genomic loci with one guide RNA per locus

open access: yesNature Communications, 2020
Three-dimensional (3D) structures of the genome are dynamic, heterogeneous and functionally important. Live cell imaging has become the leading method for chromatin dynamics tracking.
Patricia A. Clow   +5 more
semanticscholar   +1 more source

The theory and art of corneal cross-linking

open access: yesIndian Journal of Ophthalmology, 2013
Before the discovery of corneal cross-linking (CXL), patients with keratoconus would have had to undergo corneal transplantation, or wear rigid gas permeable lenses (RGPs) that would temporarily flatten the cone, thereby improving the vision.
Rebecca McQuaid   +2 more
doaj   +1 more source

Not All That Glitters Is Gold: The Paradox of CO-dependent Hydrogenogenesis in Parageobacillus thermoglucosidasius

open access: yesFrontiers in Microbiology, 2021
The thermophilic bacterium Parageobacillus thermoglucosidasius has recently gained interest due to its ability to catalyze the water gas shift reaction, where the oxidation of carbon monoxide (CO) is linked to the evolution of hydrogen (H2) gas.
Habibu Aliyu   +2 more
doaj   +1 more source

Meta‐analysis: Congruence of genomic and phenotypic differentiation across diverse natural study systems

open access: yesEvolutionary Applications, 2021
Linking genotype to phenotype is a primary goal for understanding the genomic underpinnings of evolution. However, little work has explored whether patterns of linked genomic and phenotypic differentiation are congruent across natural study systems and ...
Zachary T. Wood   +8 more
doaj   +1 more source

Mapping reduced introgression loci to the X chromosome of the hybridizing field crickets, Gryllus firmus and G. pennsylvanicus.

open access: yesPLoS ONE, 2018
The genomic architecture of barriers to gene exchange during the speciation process is poorly understood. The genomic islands model suggests that loci associated with barriers to gene exchange prevent introgression of nearby genomic regions via linkage ...
D Patrick Gainey   +2 more
doaj   +1 more source

Genomic imprinting: recognition and marking of imprinted loci [PDF]

open access: yesCurrent Opinion in Genetics & Development, 2012
Genomic imprinting is an epigenetic process resulting in the monoallelic parent-of-origin-specific expression of a subset of genes in the mammalian genome. The parental alleles are differentially marked by DNA methylation during gametogenesis when the genomes are in separate compartments. How methylation machinery recognizes and differentially modifies
Lara K, Abramowitz, Marisa S, Bartolomei
openaire   +2 more sources

Efficient assembly of de novo human artificial chromosomes from large genomic loci

open access: yesBMC Biotechnology, 2005
Background Human Artificial Chromosomes (HACs) are potentially useful vectors for gene transfer studies and for functional annotation of the genome because of their suitability for cloning, manipulating and transferring large segments of the genome ...
Stromberg Gregory   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy