Results 1 to 10 of about 1,149,216 (219)

Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats

Frontiers in Pharmacology, 2022
Although osteoarthritis (OA) significantly affects the quality of life of the elderly, there is still no effective treatment strategy. The standardized Ginkgo biloba L.
Tianwen Ma, Tianwen Ma, Liangyu Lv, Liangyu Lv, Yue Yu, Yue Yu, Lina Jia, Lina Jia, Xiaopeng Song, Xiaopeng Song, XinYu Xu, XinYu Xu, Ting Li, Ting Li, Xuanbo Sheng, Xuanbo Sheng, Haoran Wang, Haoran Wang, Jiantao Zhang, Jiantao Zhang, Li Gao, Li Gao   +21 more
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Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats

Arthritis Research & Therapy, 2022
Background Light alteration affects the internal environment and metabolic homeostasis of the body through circadian rhythm disorders (CRD). CRD is one of the factors that induce and accelerate osteoarthritis (OA). Therefore, the aim of this study was to
Xiaopeng Song, Mingchao Zhao, Jilang Tang, Tianwen Ma, Hui Bai, Xinyu Wang, Lin Liu, Ting Li, Xinyu Xu, Xuanbo Sheng, Binger Zhao, Yingying Wang, Tiantian Wang, Yingchao Guo, Xinmin Zhang, Li Gao   +15 more
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miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5

Cancer Cell International, 2021
Background miR-198 is involved in the formation, migration, invasion, and metastasis of various malignant cancers. However, the function and mechanism of action of miR-198 in the tumorigenesis of renal cell carcinoma (RCC) remain elusive.
Chao Yuan, Zhenhong Su, Shengjie Liao, Duanzhuo Li, Zhiwen Zhou, Yawen Wang, Mingchun Quan, Lingling Zeng, Cai Lv, Chenyi Shen, Weida Gong, Jianfeng Wu, Xiaogang Chen, Wenbing Hu, Xu Lv, Wenxia Si, Xin Yu   +16 more
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Circ_0006944 aggravates LPS-induced HK2 cell injury via modulating miR-205-5p/UBL4A pathway

Autoimmunity, 2023
Circular RNAs (circRNAs) has been manifested to be involved in the development of human diseases, including sepsis-associated acute kidney injury (SA-AKI).
Fan Zhou, Dong Liu, Junwei Ye, Bingqi Li
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Blood-Derived α-Synuclein Aggregated in the Substantia Nigra of Parabiotic Mice

Biomolecules, 2021
As a pathological biomarker of Parkinson’s disease, α-synuclein is thought to be a prion-like protein, but evidence for the transmission of α-synuclein from blood to the brain is unclear.
Xizhen Ma, Leilei Chen, Ning Song, Le Qu, Jun Wang, Junxia Xie   +5 more
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Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1

Communications Biology, 2022
The circulating protein apoptosis inhibitor of macrophage (AIM) reduces kidney stone development and prevents build up, providing the basis for kidney stone disease therapy.
Kyohei Matsuura, Natsumi Maehara, Aika Hirota, Ayaka Eguchi, Keisuke Yasuda, Kaori Taniguchi, Akemi Nishijima, Nobuyuki Matsuhashi, Yoshiyuki Shiga, Rumi Ishii, Yasuhiro Iguchi, Kazunari Tanabe, Satoko Arai, Toru Miyazaki   +13 more
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Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis

Ecotoxicology and Environmental Safety, 2023
Cadmium (Cd), as one of the seventh most toxic heavy metal pollutants, widely persisted in the environment, leading to osteoblast dysfunction and ultimately Cd-related skeletal disease.
Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Gao   +6 more
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Babesia duncani in Culture and in Mouse (ICIM) Model for the Advancement of Babesia Biology, Pathogenesis and Therapy

Bio-Protocol, 2022
Babesiosis is a tick-borne disease caused by pathogens belonging to the genus Babesia. In humans, the disease presents as a malaria-like illness and can be fatal in immunocompromised and elderly people.
Vandana Kumari, Anasuya Pal, Pallavi Singh, Choukri Ben Mamoun   +3 more
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CALM1 promotes progression and dampens chemosensitivity to EGFR inhibitor in esophageal squamous cell carcinoma

Cancer Cell International, 2021
Background Calmodulin1 (CALM1) has been identified as one of the overexpression genes in a variety of cancers and EGFR inhibitor have been widely used in clinical treatment but it is unknown whether CALM1 and epidermal growth factor receptor (EGFR) have ...
Tao Liu, Xiujuan Han, Shutao Zheng, Qing Liu, Aerziguli Tuerxun, Qiqi Zhang, Lifei Yang, Xiaomei Lu   +7 more
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Insights Into the Role of the Lung Virome During Respiratory Viral Infections

Frontiers in Immunology, 2022
The virome constitutes the viral component of the microbiome and it consists of the genomes of all the viruses that inhabit a particular region of the human body, including those that cause acute, persistent or latent infection, and retroviral elements ...
Bárbara N. Porto, Bárbara N. Porto
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