Results 11 to 20 of about 1,149,216 (219)

Realization of Amyloid-like Aggregation as a Common Cause for Pathogenesis in Diseases

Life, 2023
Amyloids were conventionally referred to as extracellular and intracellular accumulation of Aβ42 peptide, which causes the formation of plaques and neurofibrillary tangles inside the brain leading to the pathogenesis in Alzheimer’s disease. Subsequently,
Soumick Naskar, Nidhi Gour
doaj   +1 more source

Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition

Scientific Reports, 2017
Our recent studies revealed that supplementation with the reduced form of coenzyme Q10 (CoQ10H2) inhibits oxidative stress and slows the process of aging in senescence-accelerated mice.
Zhe Xu, Jia Huo, Xin Ding, Mu Yang, Lin Li, Jian Dai, Kazunori Hosoe, Hiroshi Kubo, Masayuki Mori, Keiichi Higuchi, Jinko Sawashita   +10 more
doaj   +1 more source

Extracellular Vesicles in Acute Leukemia: A Mesmerizing Journey With a Focus on Transferred microRNAs

Frontiers in Cell and Developmental Biology, 2021
Despite their small size, the membrane-bound particles named extracellular vesicles (EVs) seem to play an enormous role in the pathogenesis of acute leukemia.
Mehrdad Izadirad, Zoufang Huang, Farideh Jafari, Amir Ali Hamidieh, Ahmad Gharehbaghian, Yi-Dong Li, Leila Jafari, Zhe-Sheng Chen, Zhe-Sheng Chen   +8 more
doaj   +1 more source

Sensor Sensibility—HIV-1 and the Innate Immune Response

Cells, 2020
Innate immunity represents the human immune system’s first line of defense against a pathogenic intruder and is initiated by the recognition of conserved molecular structures known as pathogen-associated molecular patterns (PAMPs) by specialized ...
Xin Yin, Simon Langer, Zeli Zhang, Kristina M. Herbert, Sunnie Yoh, Renate König, Sumit K. Chanda   +6 more
doaj   +1 more source

Breaking Bad: Inflammasome Activation by Respiratory Viruses

Biology, 2023
The nucleotide-binding domain leucine-rich repeat-containing receptor (NLR) family is a group of intracellular sensors activated in response to harmful stimuli, such as invading pathogens.
Julia A. Cerato, Emanuelle F. da Silva, Barbara N. Porto   +2 more
doaj   +1 more source

Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK

Molecules, 2023
Luteoloside has shown anti-inflammatory, antiviral, and antitumor properties. However, the effect and mechanism of luteoloside on neuroblastoma cells remain unknown.
Ya He, Maohong Luo, Shan Lei, Zhirui Zeng, Tengxiang Chen, Yingmin Wu, Dongyan Wang, Long Wang, Lu Wang   +8 more
doaj   +1 more source

Exercise training based on individual physical fitness and interval walking training to prevent lifestyle-related diseases in middle-aged and older people

Journal of Physical Fitness and Sports Medicine, 2012
Physical inactivity contributes to type II diabetes, cardiovascular disease, depression, dementia, and cancer, defined as the “diseasome of physical inactivity”; however, there is no exercise training regimen broadly available in the field to prevent ...
Hiroshi Nose, Mayuko Morikawa, Shizue Masuki, Ken Miyagawa, Yoshi-ichiro Kamijo, Hirokazu Gen-no   +5 more
doaj   +1 more source

From design to clinic: Engineered peptide nanomaterials for cancer immunotherapy

Frontiers in Chemistry, 2023
Immunotherapy has revolutionized the field of cancer therapy. Nanomaterials can further improve the efficacy and safety of immunotherapy because of their tunability and multifunctionality.
Jing-Jing Du, Zhenhong Su, Haoyi Yu, Sanhai Qin, Dongyuan Wang, Dongyuan Wang   +5 more
doaj   +1 more source

Heterogeneity across mammalian- and avian-origin A(H1N1) influenza viruses influences viral infectivity following incubation with host bacteria from the human respiratory tract

Microbiology Spectrum
Influenza A viruses (IAVs) are primarily transmitted between mammals by the respiratory route and encounter bacteria in the respiratory tract before infecting susceptible epithelial cells. Previous studies have shown that mammalian-origin IAV can bind to
Poulami Basu Thakur, Hannah A. Bullock, James Stevens, Amrita Kumar, Taronna R. Maines, Jessica A. Belser   +5 more
doaj   +1 more source

Long-term efficacy of an inactivated H5N1 whole-particle influenza vaccine in nonhuman primates

npj Vaccines
Outbreaks of H5 highly pathogenic avian influenza A viruses (HPAIVs) in animals pose a threat to humans immunologically naïve to avian influenza viruses.
Misako Nakayama, Naoko Kitagawa, Cong Thanh Nguyen, Takako Sasamura, Kyoko Takashima, Hirohito Ishigaki, Hideaki Ishida, Saori Suzuki, Yoshihiro Sakoda, Mai Quynh Le, Hiroshi Kida, Kazumasa Ogasawara, Yasushi Itoh   +12 more
doaj   +1 more source