Results 41 to 50 of about 12,664,100 (362)

The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis [PDF]

open access: yes, 2017
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal disease of prematurity. Although the precise cause is not well understood, the main risk factors thought to contribute to NEC include prematurity, formula feeding, and bacterial ...
Bolock, Alexa M   +2 more
core   +2 more sources

Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases : a review on bovine necro-haemorrhagic enteritis [PDF]

open access: yes, 2017
Bovine necro-haemorrhagic enteritis is an economically important disease caused by Clostridium perfringens type A strains. The disease mainly affects calves under intensive rearing conditions and is characterized by sudden death associated with small ...
Deprez, Piet   +6 more
core   +3 more sources

Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition

open access: yesScientific Reports, 2017
Our recent studies revealed that supplementation with the reduced form of coenzyme Q10 (CoQ10H2) inhibits oxidative stress and slows the process of aging in senescence-accelerated mice.
Zhe Xu   +10 more
doaj   +1 more source

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

open access: yesInternational Journal of Nanomedicine, 2019
Currently, 47 million people live with dementia globally, and it is estimated to increase more than threefold (~131 million) by 2050. Alzheimer’s disease (AD) is one of the major causative factors to induce progressive dementia. AD is a neurodegenerative
S. Tiwari   +4 more
semanticscholar   +1 more source

Parkinson's disease: autoimmunity and neuroinflammation [PDF]

open access: yes, 2016
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO   +9 more
core   +1 more source

Pathogenesis of Borna disease [PDF]

open access: yes, 1993
Borna disease represents a unique model of a virus-induced immunological disease of the brain. Naturally occurring in horses and sheep, the mechanisms of pathogenesis have been studied in experimental animals, namely in the rat. Many investigations have revealed that the infection of the natural hosts principally follows the same pathogenic pathways as
L, Stitz, T, Bilzer, J A, Richt, R, Rott
openaire   +2 more sources

Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK

open access: yesMolecules, 2023
Luteoloside has shown anti-inflammatory, antiviral, and antitumor properties. However, the effect and mechanism of luteoloside on neuroblastoma cells remain unknown.
Ya He   +8 more
doaj   +1 more source

Spirochetal Lipoproteins and Immune Evasion. [PDF]

open access: yes, 2017
Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes.
Boyadjian, Ani   +2 more
core   +1 more source

Sensor Sensibility—HIV-1 and the Innate Immune Response

open access: yesCells, 2020
Innate immunity represents the human immune system’s first line of defense against a pathogenic intruder and is initiated by the recognition of conserved molecular structures known as pathogen-associated molecular patterns (PAMPs) by specialized ...
Xin Yin   +6 more
doaj   +1 more source

Insights Into the Role of the Lung Virome During Respiratory Viral Infections

open access: yesFrontiers in Immunology, 2022
The virome constitutes the viral component of the microbiome and it consists of the genomes of all the viruses that inhabit a particular region of the human body, including those that cause acute, persistent or latent infection, and retroviral elements ...
Bárbara N. Porto, Bárbara N. Porto
doaj   +1 more source

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