Results 61 to 70 of about 6,660,576 (307)

Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing

Bioactive Materials, 2023
Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and ...
Nanbo Liu, Shuoji Zhu, Yuzhi Deng, Ming Xie, Mingyi Zhao, Tucheng Sun, Changjiang Yu, Ying Zhong, Rui Guo, Keluo Cheng, Dehua Chang, Ping Zhu   +11 more
doaj   +1 more source

The potential role of dietary polyphenols in Parkinson’s disease [PDF]

, 2011
Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology
Vassallo, Neville, Caruana Grech Perry, Mario   +1 more
core  

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease. [PDF]

, 2014
Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status. Inhibiting the PPP in neuronal cell models causes cell death.
Allen, GF, Holton, Janice L., Dunn, L, Pope, Simon, Li, A, Lees, A, Li, Abi, Ling, Helen, Lees, Andrew, Heales, SJ, Duberley, KE, Hargreaves, Iain P., Dunn, Laura, Allen, George F. G., Mamais, A, Mamais, Adamantios, Bandopadhyay, Rina, Hargreaves, IP, Holton, JL, Bandopadhyay, R, Ling, H, Duberley, Kate E., Pope, S, Heales, Simon J.   +23 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Applications of cell penetrating peptide-based drug delivery system in immunotherapy

Frontiers in Immunology
Cell penetrating peptides (CPPs) are usually positive charged peptides and have good cell membrane permeability. Meanwhile, CPPs are facile to synthesize, and can be functionalized to satisfy different demands, such as cyclization, incorporating ...
Jing-Jing Du, Ru-Yan Zhang, Shangchi Jiang, Shanshan Xiao, Yiting Liu, Yongheng Niu, Wen-Xiang Zhao, Dongyuan Wang, Dongyuan Wang, XianShi Ma   +9 more
doaj   +1 more source

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators.
Hongwei Yao, Yao, Hongwei, Rahman, Irfan, Irfan Rahman   +3 more
core   +1 more source

Autophagy in the Pathogenesis of Disease

Cell, 2008
Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-
Levine, Beth, Kroemer, Guido
openaire   +2 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The pathogenesis of Acanthamoeba infections: current status and future implications [PDF]

, 2004
Acanthamoeba are opportunistic protozoan parasites that can cause painful, visionthreatening keratitis. However the pathogenesis and pathophysiology of Acanthamoeba keratitis remain incompletely understood. Most cases of Acanthamoeba keratitis develop
Khan, Naveed Ahmed
core   +4 more sources

Experimental Infection: Pathogenesis of neurobehavioral Disease

, 2002
Even though findings obtained from experimental Borna disease virus (BDV) infection of other species gave many insights into species-specific pathogenic processes, BDV infection of the rat is the most common model for studying the pathogenesis of Borna ...
Stitz, Lothar, Pletnikov, M.V., Gonzalez-Dunia, D.   +2 more
core   +1 more source