Results 61 to 70 of about 12,664,100 (362)

Eosinophils and Disease Pathogenesis [PDF]

Seminars in Hematology, 2012
Eosinophils are granulocytic innate immune cells whose presence is conspicuous in a variety of disease states, including eosinophilic hyperproliferative and infiltrative processes, as well as conditions associated with maladaptive Th2 inflammation.
Akuthota, Praveen, Weller, Peter
openaire   +3 more sources

Exercise training based on individual physical fitness and interval walking training to prevent lifestyle-related diseases in middle-aged and older people

Journal of Physical Fitness and Sports Medicine, 2012
Physical inactivity contributes to type II diabetes, cardiovascular disease, depression, dementia, and cancer, defined as the “diseasome of physical inactivity”; however, there is no exercise training regimen broadly available in the field to prevent ...
Hiroshi Nose, Mayuko Morikawa, Shizue Masuki, Ken Miyagawa, Yoshi-ichiro Kamijo, Hirokazu Gen-no   +5 more
doaj   +1 more source

Blood–brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy

Translational Neurodegeneration
There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson’s disease (PD), the second most common neurodegenerative disorder with rapidly rising prevalence. Altered tight junction and transporter protein levels, accumulation of α-
Kristina Lau, Rebecca Kotzur, Franziska Richter   +2 more
semanticscholar   +1 more source

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis.

Neuron, 2020
Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer disease (AD).
Yun Chen, M. Strickland, Andrea Soranno, D. Holtzman   +3 more
semanticscholar   +1 more source

Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: Implication in peripheral inflammation [PDF]

, 2018
Multiple Sclerosis (MS) is an autoimmune disease, having not fully understood aetiology, and both genetic and environmental factors contribute to the pathogenesis of the disease.
Costantini, Erica, D'Angelo, Chiara, D'Aurora, Marco, Di Bari, Maria, Di Nicola, Marta, Franchi, Sara, Galizia, Sabrina, Gasperini, Claudio, Gatta, Valentina, Orlando, Viviana, Reale, Marcella, Ruggieri, Serena, Stuppia, Liborio, Tata, Ada Maria   +13 more
core   +3 more sources

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

Heterogeneity across mammalian- and avian-origin A(H1N1) influenza viruses influences viral infectivity following incubation with host bacteria from the human respiratory tract

Microbiology Spectrum
Influenza A viruses (IAVs) are primarily transmitted between mammals by the respiratory route and encounter bacteria in the respiratory tract before infecting susceptible epithelial cells. Previous studies have shown that mammalian-origin IAV can bind to
Poulami Basu Thakur, Hannah A. Bullock, James Stevens, Amrita Kumar, Taronna R. Maines, Jessica A. Belser   +5 more
doaj   +1 more source

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients [PDF]

, 2003
The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease.
Folwaczny, Christian, Glas, J., Lohse, P., Török, H. P.   +3 more
core   +1 more source

Pathogenesis of Kawasaki disease

Clinical and Experimental Immunology, 2011
Summary Kawasaki disease (KD) most frequently affects infants and young children under 5 years of age. This disease is considered a kind of systemic vasculitis syndrome, and primarily invades the medium-sized muscular arteries, including coronary arteries.
K, Takahashi, T, Oharaseki, Y, Yokouchi
openaire   +3 more sources

Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein

Life, 2021
The immunobullous condition Pemphigus Vulgaris (PV) is caused by autoantibodies targeting the adhesion proteins of desmosomes, leading to blistering in the skin and mucosal membrane.
Ambreen Rehman, Yunying Huang, Hong Wan
doaj   +1 more source