Results 51 to 60 of about 12,664,100 (362)
Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses
Aging and Disease, 2023 Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of all dementia cases worldwide.
M. Nasb, Weichu Tao, N. Chen
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Exploring metabolic dysfunction in chronic kidney disease [PDF]
, 2012 Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk ...
Slee, Adrian D.
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Realization of Amyloid-like Aggregation as a Common Cause for Pathogenesis in Diseases
Life, 2023 Amyloids were conventionally referred to as extracellular and intracellular accumulation of Aβ42 peptide, which causes the formation of plaques and neurofibrillary tangles inside the brain leading to the pathogenesis in Alzheimer’s disease. Subsequently,
Soumick Naskar, Nidhi Gour
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Oxidative stress in the pathogenesis of systemic scleroderma: An overview [PDF]
, 2018 Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability
Gambardella, Lucrezia +5 more
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Frontiers in Cell and Developmental Biology, 2021 Despite their small size, the membrane-bound particles named extracellular vesicles (EVs) seem to play an enormous role in the pathogenesis of acute leukemia.
Mehrdad Izadirad +8 more
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Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome [PDF]
, 2019 Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology.
Barbera L. L. +5 more
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Autophagy in Alzheimer's Disease Pathogenesis: Therapeutic Potential and Future Perspectives.
Ageing Research Reviews, 2020 Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the most common cause of human dementia. AD is characterized by accumulation of abnormal protein aggregates including amyloid plaques (composed of beta-amyloid (Aβ ...
Zhigang Zhang +3 more
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From design to clinic: Engineered peptide nanomaterials for cancer immunotherapy
Frontiers in Chemistry, 2023 Immunotherapy has revolutionized the field of cancer therapy. Nanomaterials can further improve the efficacy and safety of immunotherapy because of their tunability and multifunctionality.
Jing-Jing Du +5 more
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Ulcerative colitis: Recent advances in the understanding of disease pathogenesis
F1000Research, 2020 Inflammatory bowel diseases are common, complex, immune-mediated conditions with a sharply rising global prevalence. While major advances since 2000 have provided strong mechanistic clues implicating a de-regulation in the normal interaction among host ...
R. Porter, R. Kalla, G. Ho
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Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum [PDF]
, 2005 In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease ...
Cruts, Marc +5 more
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