Results 31 to 40 of about 1,149,216 (219)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages

Scientific Reports
Diabetic kidney disease (DKD) is the main cause of deaths due to diabetes mellitus (DM). Due to the complexity of its onset, it is difficult to achieve accurate prevention and treatment. The classically activated macrophage (M1) polarization is a crucial
Xia Li, Hehua Long, Rui Peng, Xue Zou, Siyang Zuo, Yuan Yang, Min Chen, Huixiong Yuan, Zeying Liu, Teng Wang, Qingqing Zhao, Bing Guo, Lirong Liu   +12 more
doaj   +1 more source

Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing

Bioactive Materials, 2023
Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and ...
Nanbo Liu, Shuoji Zhu, Yuzhi Deng, Ming Xie, Mingyi Zhao, Tucheng Sun, Changjiang Yu, Ying Zhong, Rui Guo, Keluo Cheng, Dehua Chang, Ping Zhu   +11 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Targeting MCR-3 and membrane biosynthesis: mechanistic insights into pterostilbene-colistin synergy

Microbiology Spectrum
Colistin is a crucial antibiotic for treating infections caused by multidrug-resistant Enterobacterales. However, the emergence of plasmid-mediated mcr genes has significantly compromised their clinical efficacy. Natural adjuvants, such as pterostilbene,
Fei Zeng, Wenjuan Yin, Huilian Duan, Shuxin He, Luying Sun, Jie Zhang, Siming Wang, Feng Liu, Yuangong Zhang   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Applications of cell penetrating peptide-based drug delivery system in immunotherapy

Frontiers in Immunology
Cell penetrating peptides (CPPs) are usually positive charged peptides and have good cell membrane permeability. Meanwhile, CPPs are facile to synthesize, and can be functionalized to satisfy different demands, such as cyclization, incorporating ...
Jing-Jing Du, Ru-Yan Zhang, Shangchi Jiang, Shanshan Xiao, Yiting Liu, Yongheng Niu, Wen-Xiang Zhao, Dongyuan Wang, Dongyuan Wang, XianShi Ma   +9 more
doaj   +1 more source

Effects of balance training in addition to auxiliary activity on balance function of patients with stroke at high risk for falls

Frontiers in Neurology, 2023
ObjectiveThe aim of this study was to investigate the effect of balance training in addition to auxiliary activity on the balance function of patients with stroke at high risk for falls.MethodsA total of 112 patients with stroke at high risk for falls in
Huiqun Tan, Huiqun Tan, Zhaohui Gong, Zhaohui Gong, Sisi Xing, Sisi Xing, Lanhua Cao, Lanhua Cao, Huan Liu, Huan Liu, Lijun Xu, Lijun Xu   +11 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source