Results 21 to 30 of about 12,664,100 (362)
miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5
Cancer Cell International, 2021 Background miR-198 is involved in the formation, migration, invasion, and metastasis of various malignant cancers. However, the function and mechanism of action of miR-198 in the tumorigenesis of renal cell carcinoma (RCC) remain elusive.
Chao Yuan +16 more
doaj +1 more source
Nature Genetics, 2021 Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer’s disease (AD)1,2, but how these loci confer AD risk is unclear. Here, we aimed to identify loci that confer AD risk through their effects on brain protein abundance to ...
A. Wingo +16 more
semanticscholar +1 more source
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak
Journal of Autoimmunity, 2020 Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market
H. Rothan, S. Byrareddy
semanticscholar +1 more source
Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
International Journal of Molecular Sciences, 2021 Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix as a response to different types of tissue injuries, which leads to organ dysfunction.
Sara Panizo +8 more
semanticscholar +1 more source
Mitophagy in neurodegenerative disease pathogenesis
Neural Regeneration Research, 2023 Mitochondria are critical cellular energy resources and are central to the life of the neuron. Mitophagy selectively clears damaged or dysfunctional mitochondria through autophagic machinery to maintain mitochondrial quality control and homeostasis ...
Kan Yang +9 more
semanticscholar +1 more source
The Role of Glymphatic System in Alzheimer’s and Parkinson’s Disease Pathogenesis
Biomedicines, 2022 Alzheimer’s disease (AD) is the most common cause of neurodegenerative dementia, whilst Parkinson’s disease (PD) is a neurodegenerative movement disorder.
F. R. Buccellato +4 more
semanticscholar +1 more source
LRG1: an emerging player in disease pathogenesis
Journal of Biomedical Sciences, 2022 The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago.
C. Camilli +4 more
semanticscholar +1 more source
Blood-Derived α-Synuclein Aggregated in the Substantia Nigra of Parabiotic Mice
Biomolecules, 2021 As a pathological biomarker of Parkinson’s disease, α-synuclein is thought to be a prion-like protein, but evidence for the transmission of α-synuclein from blood to the brain is unclear.
Xizhen Ma +5 more
doaj +1 more source
Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis
Frontiers in Cellular and Infection Microbiology, 2022 The ability to form biofilms is a crucial virulence trait for several microorganisms, including Klebsiella pneumoniae – a Gram-negative encapsulated bacterium often associated with nosocomial infections.
M. E. Guerra +7 more
semanticscholar +1 more source
Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1
Communications Biology, 2022 The circulating protein apoptosis inhibitor of macrophage (AIM) reduces kidney stone development and prevents build up, providing the basis for kidney stone disease therapy.
Kyohei Matsuura +13 more
doaj +1 more source