Results 11 to 20 of about 1,321,379 (303)
Live visualization of genomic loci with BiFC-TALE [PDF]
Scientific Reports, 2017 Tracking the dynamics of genomic loci is important for understanding the mechanisms of fundamental intracellular processes. However, fluorescent labeling and imaging of such loci in live cells have been challenging.Huan Hu, Hongmin Zhang, Sheng Wang, M. Ding, Hui An, Yingping Hou, Xiaojing Yang, Wensheng Wei, Yujie Sun, Chao-shu Tang +9 moresemanticscholar +3 more sourcesMapping genomic loci implicates genes and synaptic biology in schizophrenia
Nature, 2022 Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant V. Trubetskoy, A. Pardiñas, Ting Qi, G. Panagiotaropoulou, S. Awasthi, T. Bigdeli, J. Bryois, Chia-Yen Chen, Charlotte A. Dennison, L. Hall, Max W. Y. Lam, Kyoko Watanabe, O. Frei, T. Ge, J. Harwood, F. Koopmans, S. Magnússon, A. Richards, J. Sidorenko, Yang Wu, Jian Zeng, J. Grove, Minsoo Kim, Zhiqiang Li, G. Voloudakis, Wen Zhang, M. Adams, I. Agartz, Elizabeth G. Atkinson, E. Agerbo, M. A. Al Eissa, M. Albus, Madeline Alexander, B. Alizadeh, K. Alptekin, T. Als, F. Amin, V. Arolt, M. Arrojo, L. Athanasiu, M. Azevedo, S. Bacanu, N. Bass, M. Begemann, R. Belliveau, J. Bene, Beben Benyamin, Sarah E. Bergen, G. Blasi, J. Bobes, S. Bonassi, A. Braun, R. Bressan, E. Bromet, R. Bruggeman, P. Buckley, R. Buckner, J. Bybjerg-Grauholm, W. Cahn, M. Cairns, M. Calkins, V. Carr, D. Castle, S. Catts, Kimberley D. Chambert, R. Chan, B. Chaumette, Wei Cheng, E. Cheung, S. Chong, D. Cohen, A. Consoli, Q. Cordeiro, J. Costas, C. Curtis, Michal Davidson, K. Davis, L. de Haan, F. Degenhardt, L. DeLisi, D. Demontis, F. Dickerson, D. Dikeos, T. Dinan, S. Djurovic, J. Duan, G. Ducci, F. Dudbridge, J. Eriksson, L. Fañanás, S. Faraone, A. Fiorentino, A. Forstner, J. Frank, N. Freimer, M. Fromer, A. Frustaci, A. Gadelha, G. Genovese, E. Gershon, M. Giannitelli, I. Giegling, P. Giusti-Rodríguez, S. Godard, J. Goldstein, Javier González Peñas, A. González-Pinto, S. Gopal, J. Gratten, Michael F. Green, T. Greenwood, O. Guillin, S. Gülöksüz, R. Gur, R. Gur, B. Gutiérrez, E. Hahn, H. Hakonarson, V. Haroutunian, A. Hartmann, C. Harvey, C. Hayward, F. Henskens, S. Herms, P. Hoffmann, D. Howrigan, M. Ikeda, C. Iyegbe, I. Joa, A. Julià, A. Kähler, Tony Kam-Thong, Y. Kamatani, Sena Karachanak-Yankova, O. Kebir, M. Keller, Brian J. Kelly, A. Khrunin, Sung-Wan Kim, J. Kloviņš, N. Kondratiev, B. Konte, J. Kraft, M. Kubo, V. Kučinskas, Z. Kučinskienė, A. Kusumawardhani, Hana Kuzelova-Ptackova, S. Landi, L. Lazzeroni, Phil H. Lee, S. Legge, D. Lehrer, R. Lencer, B. Lerer, Miaoxin Li, J. Lieberman, G. Light, S. Limborska, Chih-Min Liu, J. Lönnqvist, C. Loughland, J. Lubiński, J. Luykx, A. Lynham, M. Macek, Andrew Mackinnon, P. Magnusson, B. Maher, W. Maier, D. Malaspina, J. Mallet, S. Marder, S. Marsal, Alicia R. Martin, L. Martorell, M. Mattheisen, R. McCarley, C. Mcdonald, J. McGrath, H. Medeiros, S. Meier, B. Melegh, I. Melle, R. Mesholam-Gately, A. Metspalu, P. Michie, L. Milani, V. Milanova, M. Mitjans, E. Molden, E. Molina, M. Moltó, V. Mondelli, C. Moreno, C. Morley, G. Muntané, K. Murphy, I. Myin-Germeys, I. Nenadić, G. Nestadt, L. Nikitina-Zake, Cristiano Noto, K. Nuechterlein, N. O’Brien, F. O'Neill, Sang-Yun Oh, A. Olincy, V. Ota, C. Pantelis, G. Papadimitriou, M. Parellada, T. Paunio, R. Pellegrino, S. Periyasamy, D. Perkins, B. Pfuhlmann, O. Pietiläinen, J. Pimm, D. Porteous, J. Powell, D. Quattrone, D. Quested, A. Radant, A. Rampino, M. Rapaport, A. Rautanen, A. Reichenberg, Cheryl A. Roe, J. Roffman, Julian Roth, M. Rothermundt, B. Rutten, Safa Saker-Delye, V. Salomaa, J. Sanjuán, M. Santoro, A. Savitz, U. Schall, Rodney J. Scott, L. Seidman, S. Sharp, Jianxin Shi, L. Siever, E. Sigurdsson, K. Sim, Nora Skarabis, P. Slominsky, H. So, J. Sobell, E. Söderman, H. Stain, N. E. Steen, Agnes A. Steixner-Kumar, Elisabeth Stögmann, W. Stone, R. Straub, F. Streit, E. Strengman, T. Stroup, M. Subramaniam, Catherine A. Sugar, J. Suvisaari, D. Svrakic, N. Swerdlow, J. Szatkiewicz, T. Ta, A. Takahashi, C. Terao, F. Thibaut, D. Toncheva, P. Tooney, Silvia Torretta, S. Tosato, G. Tura, B. Turetsky, A. Üçok, A. Vaaler, T. van Amelsvoort, R. van Winkel, J. Veijola, J. Waddington, H. Walter, A. Waterreus, B. Webb, M. Weiser, Nigel M Williams, S. Witt, B. Wormley, J. Wu, Zhida Xu, R. Yolken, C. Zai, Wei Zhou, Feng Zhu, F. Zimprich, E. Atbasoglu, M. Ayub, C. Benner, A. Bertolino, D. Black, N. Bray, G. Breen, N. Buccola, W. Byerley, Wei J. Chen, C. Cloninger, B. Crespo-Facorro, G. Donohoe, R. Freedman, C. Galletly, Michael Jeffrey Gandal, M. Gennarelli, D. Hougaard, H. Hwu, A. Jablensky, S. Mccarroll, J. Moran, O. Mors, P. Mortensen, B. Müller-Myhsok, A. Neil, M. Nordentoft, M. Pato, T. Petryshen, M. Pirinen, A. Pulver, T. Schulze, J. Silverman, J. Smoller, E. Stahl, D. Tsuang, E. Vilella, Shi-Heng Wang, Shuhua Xu, R. Adolfsson, C. Arango, B. Baune, S. Belangero, A. Børglum, D. Braff, E. Bramon, J. Buxbaum, D. Campion, J. Cervilla, S. Cichon, David A. Collier, A. Corvin, D. Curtis, M. Forti, E. Domenici, H. Ehrenreich, V. Escott-Price, T. Esko, A. Fanous, A. Gareeva, M. Gawlik, P. Gejman, M. Gill, S. Glatt, V. Golimbet, K. Hong, C. Hultman, S. Hyman, N. Iwata, E. Jönsson, R. Kahn, James L. Kennedy, E. Khusnutdinova, G. Kirov, J. Knowles, M. Krebs, C. Laurent-Levinson, Jimmy Lee, T. Lencz, D. Levinson, Qingqin S. Li, J. Liu, A. Malhotra, D. Malhotra, A. McIntosh, A. McQuillin, P. Menezes, V. Morgan, D. Morris, B. Mowry, Robin M. Murray, V. Nimgaonkar, M. Nöthen, R. Ophoff, S. Paciga, A. Palotie, C. Pato, Shengying Qin, M. Rietschel, B. Riley, M. Rivera, D. Rujescu, M. Saka, A. Sanders, S. Schwab, A. Serretti, P. Sham, Yongyong Shi, D. St. Clair, H. Stefánsson, K. Stefánsson, M. Tsuang, J. van os, M. Vawter, D. Weinberger, T. Werge, D. Wildenauer, Xin Yu, W. Yue, P. Holmans, A. Pocklington, P. Roussos, E. Vassos, M. Verhage, P. Visscher, Jian Yang, D. Posthuma, O. Andreassen, K. Kendler, M. Owen, N. Wray, M. Daly, Hailiang Huang, B. Neale, Patrick F. Sullivan, S. Ripke, J. Walters, M. O’Donovan +433 moresemanticscholar +1 more sourceDiscovery of genomic loci of the human cerebral cortex using genetically informed brain atlases
Science, 2022 To determine the impact of genetic variants on the brain, we used genetically informed brain atlases in genome-wide association studies of regional cortical surface area and thickness in 39,898 adults and 9136 children.C. Makowski, D. van der Meer, Weixiu Dong, Hao Wang, Yan Wu, J. Zou, Cin Liu, S. Rosenthal, D. Hagler, C. Fan, W. Kremen, O. Andreassen, T. Jernigan, A. Dale, Kun Zhang, P. Visscher, Jian Yang, Chi-Hua Chen +17 moresemanticscholar +1 more sourcePerformance of Genomic Bordering Elements at Predefined Genomic Loci [PDF]
Molecular and Cellular Biology, 2005 Eukaryotic DNA is organized into chromatin domains that regulate gene expression and chromosome behavior. Insulators and/or scaffold-matrix attachment regions (S/MARs) mark the boundaries of these chromatin domains where they delimit enhancing and silencing effects from the outside.Goetze, Sandra, Baer, Alexandra, Winkelmann, Silke, Nehlsen, Kristina, Seibler, Jost (Prof. Dr.), Maass, Karin, Bode, Jürgen +6 moreopenaire +3 more sourcesComplex Loci in Human and Mouse Genomes
PLoS Genetics, 2006 Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core promoters. To determine the incidence, functional significance, and evolutionary context of mammalian complex loci, we identified and characterized 5,248 cis ...Engstrom, PG, Suzuki, H, Ninomiya, N, Akalin, A, Sessa, L, Lavorgna, G, Brozzi, A, Luzi, L, Tan, SL, Yang, L, Kunarso, G, ng, EL-CN, Batalov, S, Wahlestedt, C, Kai, C, Kawai, J, Carninci, P, Hayashizaki, Y, Wells, C, Bajic, VB, Orlando, V, Reid, JF, Lenhard, B, Lipovich, L +23 more +13 more sourcesVisualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells
bioRxiv, 2021 In eukaryotic nuclei, chromatin loops mediated through cohesin are critical structures that regulate gene expression and DNA replication. Here we demonstrate a new method to visualize endogenous genomic loci using synthetic zinc-finger proteins harboring Yang Liu, Ning Zhao, Masato T. Kanemaki, Yotaro Yamamoto, Yoshifusa Sadamura, Yuma Ito, M. Tokunaga, T. Stasevich, H. Kimura +8 moresemanticscholar +1 more source
