Results 11 to 20 of about 1,069,336 (306)

Genome composition and GC content influence loci distribution in reduced representation genomic studies [PDF]

open access: yesBMC Genomics
Background Genomic architecture is a key evolutionary trait for living organisms. Due to multiple complex adaptive and neutral forces which impose evolutionary pressures on genomes, there is a huge variability of genomic features.
Carles Galià-Camps   +4 more
doaj   +2 more sources

Performance of Genomic Bordering Elements at Predefined Genomic Loci [PDF]

open access: yesMolecular and Cellular Biology, 2005
Eukaryotic DNA is organized into chromatin domains that regulate gene expression and chromosome behavior. Insulators and/or scaffold-matrix attachment regions (S/MARs) mark the boundaries of these chromatin domains where they delimit enhancing and silencing effects from the outside.
Goetze, Sandra   +6 more
openaire   +3 more sources

Author Correction: Fine-mapping genomic loci refines bipolar disorder risk genes. [PDF]

open access: yesNat Neurosci
Correction to "Fine-mapping genomic loci refines bipolar disorder risk ...
Koromina M   +132 more
europepmc   +2 more sources

Complex Loci in Human and Mouse Genomes

open access: yesPLoS Genetics, 2006
Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core promoters. To determine the incidence, functional significance, and evolutionary context of mammalian complex loci, we identified and characterized 5,248 cis ...
Engstrom, PG   +23 more
openaire   +11 more sources

GLANET: genomic loci annotation and enrichment tool [PDF]

open access: yesBioinformatics, 2017
AbstractMotivationGenomic studies identify genomic loci representing genetic variations, transcription factor (TF) occupancy, or histone modification through next generation sequencing (NGS) technologies. Interpreting these loci requires evaluating them with known genomic and epigenomic annotations.ResultsWe present GLANET as a comprehensive annotation
Burçak Otlu   +3 more
openaire   +5 more sources

Comparative genomics of vertebrate Fox cluster loci [PDF]

open access: yesBMC Genomics, 2006
Vertebrate genomes contain numerous duplicate genes, many of which are organised into paralagous regions indicating duplication of linked groups of genes. Comparison of genomic organisation in different lineages can often allow the evolutionary history of such regions to be traced.
Wotton, KR, Shimeld, SM
openaire   +5 more sources

Evolutionary Genomics of Immunoglobulin-Encoding Loci in Vertebrates [PDF]

open access: yesCurrent Genomics, 2012
Immunoglobulins (or antibodies) are an essential element of the jawed vertebrate adaptive immune response system. These molecules have evolved over the past 500 million years and generated highly specialized proteins that recognize an extraordinarily large number of diverse substances, collectively known as antigens.
Das, Sabyasachi   +4 more
openaire   +2 more sources

Genome-wide significant loci for addiction and anxiety [PDF]

open access: yesEuropean Psychiatry, 2016
AbstractBackgroundPsychiatric comorbidity is common among individuals with addictive disorders, with patients frequently suffering from anxiety disorders. While the genetic architecture of comorbid addictive and anxiety disorders remains unclear, elucidating the genes involved could provide important insights into the underlying etiology.MethodsHere we
K, Hodgson   +13 more
openaire   +2 more sources

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci [PDF]

open access: yes, 2013
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat
Burke, Gregory L.   +431 more
core   +1 more source

The theory and art of corneal cross-linking

open access: yesIndian Journal of Ophthalmology, 2013
Before the discovery of corneal cross-linking (CXL), patients with keratoconus would have had to undergo corneal transplantation, or wear rigid gas permeable lenses (RGPs) that would temporarily flatten the cone, thereby improving the vision.
Rebecca McQuaid   +2 more
doaj   +1 more source

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