Results 91 to 100 of about 4,320,960 (307)

Deep anterior lamellar keratoplasty in the management of keratoconus

Indian Journal of Ophthalmology, 2013
Advanced cases of keratoconus often require surgical intervention to restore corneal anatomy and improve eyesight. Penetrating keratoplasty (PK) although commonly performed has potential risk of immunological rejection and is now no longer automatically ...
Rajesh Fogla
doaj   +1 more source

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

bioRxiv, 2018
Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we whole-exome sequenced (WES) three anatomically distinct regions of the same ...
W. Shi, C. Ng, R. Lim, T. Jiang, Sushant Kumar, Xiaotong Li, V. Wali, S. Piscuoglio, M. Gerstein, A. Chagpar, B. Weigelt, L. Pusztai, J. Reis-Filho, C. Hatzis   +13 more
semanticscholar   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Review of current indications for combined very high fluence collagen cross-linking and laser in situ keratomileusis surgery

Indian Journal of Ophthalmology, 2013
In this brief review we will discuss the reasoning and evolution of our current use of combined very high-fluence collagen crosslinking and laser in situ keratomileusis.
Anastasios John Kanellopoulos, Gregory J Pamel   +1 more
doaj   +1 more source

Evidence for Genetic Heterogeneity in Monilethrix

Journal of Investigative Dermatology, 1996
Monilethrix is a rare inherited defect of the hair shaft resulting in hair fragility and dystrophic alopecia. In contrast to recent reports mapping monilethrix to the type II epithelial and trichocyte keratin gene cluster on 12q13, we strongly excluded these candidate genes in another family with autosomal dominant monilethrix.
Richard, Gabriela, Itin, Peter, Lin, Jing Ping, Bon, Anita, Bale, Sherri J.   +4 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Genetic Heterogeneity of Hepatitis E Virus (HEV) in Wild Boars in Italy

Animals
Hepatitis E virus (HEV) is an emerging zoonotic pathogen in Europe, where most autochthonous infections are caused by genotype 3 (HEV-3) and are due to ingestion of raw or undercooked pork meat products.
Vittorio Sarchese, Federica Di Profio, Matteo Carnevale, Roberta Battistini, Barbara Moroni, Lisa Guardone, Serena Robetto, Riccardo Orusa, Fulvio Marsilio, Vito Martella, Barbara Di Martino   +10 more
doaj   +1 more source

The theory and art of corneal cross-linking

Indian Journal of Ophthalmology, 2013
Before the discovery of corneal cross-linking (CXL), patients with keratoconus would have had to undergo corneal transplantation, or wear rigid gas permeable lenses (RGPs) that would temporarily flatten the cone, thereby improving the vision.
Rebecca McQuaid, Arthur B Cummings, Michael Mrochen   +2 more
doaj   +1 more source

The immune system profoundly restricts intratumor genetic heterogeneity

Science immunology, 2018
Host immune responses and checkpoint inhibition reduce clonal and genetic intratumor diversity. Immunoediting of polychromatic tumors As tumors grow, they evolve genetically.
Idan Milo, Marie Bedora-Faure, Z. Garcia, Ronan Thibaut, L. Perié, G. Shakhar, L. Deriano, P. Bousso   +7 more
semanticscholar   +1 more source