Results 121 to 130 of about 5,062,045 (260)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Robustly enhancing crop genomic prediction accuracy through ensemble learning and iterative optimization

Nature Communications
With climate change and global population growth, accelerating the breeding of superior crop varieties is essential for food security. Genomic prediction, which uses genome-wide genetic markers to predict crop traits, plays an important role in ...
Zhou Yao, Liguang Wang, Li Zhu, Xinle Li, Qiqi Wu, Fan Wu, Guoshuai Wang, Wenyu Yang, Yingjie Xiao, Jianxiao Liu   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Social care division/quality improvement division QI programme newsletter September 2016

, 2016
Programme newsletter for the social care division/quality improvement division quality improvement ...
National Quality Improvement Team
core  

Sorghum improvement in Eastern Africa : proceedings of the Regional Workshop on Sorghum Improvement in Eastern Africa, 17-21 Oct., 1982, Nazreth and Debre Zeit, Ethiopia

, 1983
Meeting: Regional Workshop on Sorghum Improvement in Eastern Africa, 17-21 Oct. 1982, Nazreth, ETMeeting: Regional Workshop on Sorghum Improvement in Eastern Africa, 17-21 Oct.

core   +1 more source

Effect of Altitude on the Agronomic Performance of Four Improved Maize Varieties Under Dissemination in Côte d’Ivoire

International Journal of Agronomy
Maize is a staple crop for millions, yet its production in Côte d’Ivoire remains below potential despite advances in improved varieties. Environmental conditions, including altitude, potentially influence maize performance, but data on altitude’s effect ...
Lassana Tioté, Yaya Nadiala Coulibaly, Yao Raymond Koffi   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Crop genetic resource policy: the role of ex situ genebanks [PDF]

The world-wide capacity of genebanks for ex situ conservation of crop genetic resources has increased greatly since the 1970s, improving the access of crop breeders to landraces and wild and weedy relatives.
Wright, Brian D.
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source