Results 51 to 60 of about 625,256 (313)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Synthetic Benchmarks for Genetic Improvement [PDF]

Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops, 2020
Genetic improvement (GI) uses automated search to find improved versions of existing software. If over the years the potential of many GI approaches have been demonstrated, the intrinsic cost of evaluating real-world software makes comparing these approaches in large-scale meta-analyses very expensive.
Aymeric Blot, Justyna Petke
openaire   +2 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Phenylpropanoid metabolism and pigmentation show divergent patterns between brown color and green color cottons as revealed by metabolic and gene expression analyses

Journal of Cotton Research, 2020
Background Naturally-colored cotton has become increasingly popular because of their natural properties of coloration, UV protection, flame retardant, antibacterial activity and mildew resistance.
Zhonghua LI, Qian SU, Mingqi XU, Jiaqi YOU, Anam Qadir KHAN, Junyi LI, Xianlong ZHANG, Lili TU, Chunyuan YOU   +8 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Stack-Based Genetic Improvement [PDF]

Proceedings of the IEEE/ACM 42nd International Conference on Software Engineering Workshops, 2020
Genetic improvement (GI) uses automated search to find improved versions of existing software. If originally GI directly evolved populations of software, most GI work nowadays use a solution representation based on a list of mutations. This representation however has some limitations, notably in how genetic material can be recombined.
Aymeric Blot, Justyna Petke
openaire   +2 more sources

Fast anther dehiscence status recognition system established by deep learning to screen heat tolerant cotton

Plant Methods, 2022
Background From an economic perspective, cotton is one of the most important crops in the world. The fertility of male reproductive organs is a key determinant of cotton yield.
Zhihao Tan, Jiawei Shi, Rongjie Lv, Qingyuan Li, Jing Yang, Yizan Ma, Yanlong Li, Yuanlong Wu, Rui Zhang, Huanhuan Ma, Yawei Li, Li Zhu, Longfu Zhu, Xianlong Zhang, Jie Kong, Wanneng Yang, Ling Min   +16 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Knock-out of TERMINAL FLOWER 1 genes altered flowering time and plant architecture in Brassica napus

BMC Genetics, 2020
Background TERMINAL FLOWER 1 (TFL1) is a member of phosphatidylethanolamine-binding protein (PEBP) family, which plays an important role in the determination of floral meristem identity and regulates flowering time in higher plants.
Sukarkarn Sriboon, Haitao Li, Chaocheng Guo, Thaveep Senkhamwong, Cheng Dai, Kede Liu   +5 more
doaj   +1 more source

Diurnal RNAPII-tethered chromatin interactions are associated with rhythmic gene expression in rice

Genome Biology, 2022
Background The daily cycling of plant physiological processes is speculated to arise from the coordinated rhythms of gene expression. However, the dynamics of diurnal 3D genome architecture and their potential functions underlying the rhythmic gene ...
Li Deng, Baibai Gao, Lun Zhao, Ying Zhang, Qing Zhang, Minrong Guo, Yongqing Yang, Shuangqi Wang, Liang Xie, Hao Lou, Meng Ma, Wei Zhang, Zhilin Cao, Qinghua Zhang, C. Robertson McClung, Guoliang Li, Xingwang Li   +16 more
doaj   +1 more source