Results 61 to 70 of about 5,062,045 (260)

Evolution and subfunctionalization of CIPK6 homologous genes in regulating cotton drought resistance

Nature Communications
The occurrence of whole-genome duplication or polyploidy may promote plant adaptability to harsh environments. Here, we clarify the evolutionary relationship of eight GhCIPK6 homologous genes in upland cotton (Gossypium hirsutum).
Weinan Sun, Linjie Xia, Jinwu Deng, Simin Sun, Dandan Yue, Jiaqi You, Maojun Wang, Shuangxia Jin, Longfu Zhu, Keith Lindsey, Xianlong Zhang, Xiyan Yang   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Proceedings of a workshop on the development of a genetic improvement program for African catfish Clarias gariepinus [PDF]

This proceedings include papers present at the workshop held from 5 to 9th Nov 2007 in Accra, Ghana. The areas cover 1)the present state of the catfish industry in Africa 2)Catfish reproductive management and grow out 3)Catfish nutrition and feeds 4)The ...
Ponzoni, R.W., Nguyen, N.H. (eds.)
core  

Chromatin loops associated with active genes and heterochromatin shape rice genome architecture for transcriptional regulation

Nature Communications, 2019
Three-dimensional genome organization and its effect on transcription remain elusive in rice. Here, the authors map promoter–promoter interactions and heterochromatin interactions using ChIA-PET and reveal spatial correlation between the genetic ...
Lun Zhao, Shuangqi Wang, Zhilin Cao, Weizhi Ouyang, Qing Zhang, Liang Xie, Ruiqin Zheng, Minrong Guo, Meng Ma, Zhe Hu, Wing-Kin Sung, Qifa Zhang, Guoliang Li, Xingwang Li   +13 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Preventing Blood Clots in Hospitals: Improvement Collaborative Report National Recommendations and Improvement Toolkit

, 2018
This report shares learning from the collaborative, including which factors contributed to high levels of appropriate prophylaxis and to improvement. There was a higher level of appropriateness observed in orthopaedic and post-partum patients than in ...
National Medication Safety Improvement Programme
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

On Adaptive Specialisation in Genetic Improvement [PDF]

, 2019
Genetic improvement uses automated search to find improved versions of existing software. Software can either be evolved with general-purpose intentions or with a focus on a specific application (e.g., to improve it’s efficiency for a particular class ...
Justyna Petke, Blot, A, Petke, J, Aymeric Blot   +3 more
core   +2 more sources