Results 111 to 120 of about 5,764,173 (258)

Genetic parameters for social effects on survival in cannibalistic layers: Combining survival analysis and a linear animal model [PDF]

, 2010
Background Mortality due to cannibalism in laying hens is a difficult trait to improve genetically, because censoring is high (animals still alive at the end of the testing period) and it may depend on both the individual itself and the behaviour of its ...
Veerkamp Roel F, Veerkamp, Roel F., Ducrocq, V.P., Ducrocq, Vincent, Bijma, Piter, Bijma Piter, Ducro, B.J., Esther D Ellen, Ellen, Esther D., Bijma, P., Ellen Esther D, Ellen, E.D., Veerkamp, Roel F, Roel F Veerkamp, Ducro, Bart J., Veerkamp, R.F., Vincent Ducrocq, Ducro Bart J, Bart J Ducro, Ducrocq Vincent, Ducro, Bart J, Piter Bijma   +21 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Genetics of survival in cannibalistic laying hens: The contribution of social effects [PDF]

, 2009
Mortality due to cannibalism in laying hens is a worldwide economic and welfare problem occurring in all types of commercial poultry housing systems. Due to prohibition of beak-trimming and the traditional battery system in the European Union in the near
Ellen, E.D.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The core genetic drivers of chronological aging in yeast are universal regulators of longevity

Microbial Cell
The chronological lifespan of Saccharomyces cerevisiae has significantly contributed to our understanding of aging in eukaryotic cells. However, gaining a genome-wide perspective of this trait remains challenging due to substantial discrepancies observed
Erika Cruz-Bonilla, Sergio E. Campos, Soledad Funes, Cei Abreu-Goodger, Alexander DeLuna   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

High‐resolution mapping of cancer cell networks using co‐functional interactions

Molecular Systems Biology, 2018
Powerful new technologies for perturbing genetic elements have recently expanded the study of genetic interactions in model systems ranging from yeast to human cell lines.
Evan A Boyle, Jonathan K Pritchard, William J Greenleaf   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Modelling the Consequences of Domestication‐Introgression in Wild Populations Using Genetic Markers Under Varying Degrees of Selection

Evolutionary Applications
Introgression of domesticated genomes influences the evolutionary trajectory of wild populations. Genetic markers are used to quantify admixture in wild populations subjected to introgression from non‐native conspecifics.
K. A. Glover, M. Castellani, M. Heino, F. Besnier   +3 more
doaj   +1 more source