Results 191 to 200 of about 5,764,173 (258)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes. [PDF]

Nat Commun
Makins K, Cisneros-Aguirre M, Lopezcolorado FW, Stark JM.   +3 more
europepmc   +1 more source

GENETIC SPECTRUM OF NOONAN SYNDROME IN PEDIATRIC POPULATION

Noonan syndrome (NS) is an autosomal dominant hereditary disorder with a prevalence of 1:1000 to 1:2500 live births. First described in 1963 by pediatric cardiologist Jacqueline Noonan, this syndrome is classified among RASopathies which arise from ...
Sarajlija, Adrijan, Gašić, Vladimir, Alimpić, Biljana, Pavlović, Sonja, Ilić, Nikola, Krasić, Staša, Vukomanović, Vladislav, Krstić, Jovana   +7 more
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Ancient genomes in Southwest China revealed genetic interactions among diverse populations in the historical period. [PDF]

BMC Biol
Wan W, Huang H, Hu C, Zhang X, Zhou Q, Yang M, Guo J, Xie M, Zhu K, Yang X, Ma H, Wang R, Zhao J, Tao L, He H, Zhang Q, Jin L, Zhou B, Huang J, Wang CC.   +19 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Robust Association Test Leveraging Unknown Genetic Interactions: Application to Cystic Fibrosis Lung Disease. [PDF]

Genet Epidemiol
Kim S, Lin YC, Strug LJ.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort. [PDF]

Transl Psychiatry
Garrison-Desany HM, Hinojosa CA, Tubbs JD, Meyers JL, Linnstaedt SD, House SL, Beaudoin FL, An X, Stevens JS, Neylan TC, Clifford GD, Germine LT, Rauch SL, Haran JP, Storrow AB, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Merchant RC, Domeier RM, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Harte SE, McLean SA, Ressler KJ, Koenen KC, Denckla CA.   +35 more
europepmc   +1 more source