Results 191 to 200 of about 7,541,678 (261)

Chronic Kidney Disease Initiative -- protecting kidney kealth

Chronic kidney disease (CKD) is a condition in which the kidneys are damaged and cannot filter blood as well as they should. CKD has varying levels of seriousness that can range from leakage of extra protein into the urine to kidney failure requiring ...

core  

A Pilot Study on Protective Effect of Ambrisentan on Proteinuria in Patients With Alport Syndrome

Kidney International Reports
Zhuo-ran Song, Yang Li, Hong Zhang, Xu-jie Zhou   +3 more
doaj   +1 more source

Living Kidney Transplantation in a Patient With End-Stage Kidney Disease Due to Rare Juvenile Nail-Patella-Like Renal Disease Without <i>LMX1B</i> Mutation. [PDF]

Case Rep Transplant
Okabe T, Nakajima Y, Iwatsuki K, Maenosono R, Matsuda T, Tsuchida S, Hanamori T, Fujiwara Y, Nakamori K, Matsunaga T, Yoshikawa Y, Tsujino T, Matsumura H, Nomi H, Ashida A, Azuma H.   +15 more
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

A Novel <i>LAMA5</i> Variant in Adult-Onset Focal Segmental Glomerulosclerosis: A Case Report. [PDF]

Case Rep Genet
Dahlan RA, Fairoozy RH.
europepmc   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Genetic Insights into Pediatric Polycystic Kidney Disease and Overlapping Ciliopathies: A Narrative Review. [PDF]

Genes (Basel)
Chirico V, Tripodi F, Cassaro F, Lacquaniti A, Arena S, Romeo C, Chimenz R.   +6 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Customized <i>MUC1</i> Sequencing Enables Diagnosis of Autosomal Dominant Tubulointerstitial Kidney Disease and Unexplained CKD. [PDF]

Kidney Int Rep
García-Aznar JM, Besada-Cerecedo ML, Aguirre NL, Álvarez JP, Boluda-Navarro M, Alvaredo SG, Lesende I, Castañeda-Infante L, León-Machado L, Rodríguez AS, Pérez-Gómez V, Garces EG, Ortiz A, Fresnedo GF, Vilarino MC, Criach EA, Prado de la Sierra JC, Escaño Marín RM, Velázquez MM, Blasco M, Procaccini FL, de Sequera P.   +21 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source