Results 241 to 250 of about 628,301 (302)

An observational, non-interventional, multicenter, multinational registry of patients with atypical hemolytic uremic syndrome: methodology [PDF]

, 2013
Ardissino, Gianluigi, Ariceta, Gema, Beauchamp, Jon, Cohen, David, Fremeaux-Bacchi, Veronique, Greenbaum, Larry A, Johnson, Sally, Licht, Christoph, Ogawa, Massayo, Schaefer, Franz, Vande Walle, Johan   +10 more
core  

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Gastric Neuroendocrine Tumor Presenting Atypically in von Hippel-Lindau Disease: A Case Report. [PDF]

J Kidney Cancer VHL
Chang J, Zhang Q, Liu Z, Bai Y, Ji H, Zhang HM.   +5 more
europepmc   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Molecular Mechanisms of APOL1-Associated Kidney Disease. [PDF]

Int J Mol Sci
Delrue C, Speeckaert R, Speeckaert MM.
europepmc   +1 more source

Genomic Structural Equation Modeling Reveals Cardiovascular-Kidney-Metabolic Syndrome Genetic Architecture. [PDF]

J Diabetes
Lu C, Li L, Chen J, Chang R, Dong H.
europepmc   +1 more source

From GWAS Signals to Causal Genes in Chronic Kidney Disease. [PDF]

Curr Issues Mol Biol
Delrue C, Speeckaert R, Speeckaert MM.
europepmc   +1 more source

Screening for genetic kidney diseases in a dialysis cohort via exome sequencing. [PDF]

Clin Kidney J
Liu ZY, Zhang YL, Li Y, Han JF, Song ZR, Zhang JY, Qu TH, Xu R, Zhang H, Chen XL, Zhou XJ.   +10 more
europepmc   +1 more source