Coalescence, genetic diversity in sexual populations under selection [PDF]
Proc Natl Acad Sci U S A. Sep 24, 2013; 110: 15836--15841, 2013 In sexual populations, selection operates neither on the whole genome, which is repeatedly taken apart and reassembled by recombination, nor on individual alleles that are tightly linked to the chromosomal neighborhood. The resulting interference between linked alleles reduces the efficiency of selection and distorts patterns of genetic diversity ...
Kessinger, Taylor A. +2 more
arxiv +5 more sources
Scalability of Genetic Programming and Probabilistic Incremental Program Evolution [PDF]
arXiv, 2005 This paper discusses scalability of standard genetic programming (GP) and the probabilistic incremental program evolution (PIPE). To investigate the need for both effective mixing and linkage learning, two test problems are considered: ORDER problem, which is rather easy for any recombination-based GP, and TRAP or the deceptive trap problem, which ...
Ondas, Radovan +2 more
arxiv +5 more sources
The asexual genome of Drosophila [PDF]
arXiv, 2017 The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic segments. Selection under linkage can induce clonal interference, a specific mode of evolution by competition of ...
Lässig, Michael +2 more
arxiv +3 more sources
High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene. [PDF]
, 2009 Chromosome 17q11-q21 is a region of the genome likely to harbor susceptibility to autism (MIM(209850)) based on earlier evidence of linkage to the disorder.
Cantor, RM +6 more
core +3 more sources
A Multifactorial Optimization Paradigm for Linkage Tree Genetic Algorithm [PDF]
InformationSciences. 540 (2020) 325-344, 2020 Linkage Tree Genetic Algorithm (LTGA) is an effective Evolutionary Algorithm (EA) to solve complex problems using the linkage information between problem variables. LTGA performs well in various kinds of single-task optimization and yields promising results in comparison with the canonical genetic algorithm.
arxiv +1 more source
Diversity, differentiation, and linkage disequilibrium: prospects for association mapping in the malaria vector anopheles arabiensis [PDF]
, 2013 Association mapping is a widely applied method for elucidating the genetic basis of phenotypic traits. However, factors such as linkage disequilibrium and levels of genetic diversity influence the power and resolution of this approach.
Cornel, Anthony +7 more
core +2 more sources
Genetics of autistic disorders : review and clinical implications [PDF]
, 2009 Twin and family studies in autistic disorders (AD) have elucidated a high heritability of AD. In this literature review, we will present an overview on molecular genetic studies in AD and highlight the most recent findings of an increased rate of copy ...
Duketis, Eftichia +4 more
core +4 more sources
Linkage disequilibrium under recurrent bottlenecks [PDF]
Genetics 190, 217 (2012), 2011 Understanding patterns of selectively neutral genetic variation is essential in order to model deviations from neutrality, caused for example by different forms of selection. Best understood is neutral genetic variation at a single locus, but additional insights can be gained by investigating genetic variation at multiple loci.
arxiv +1 more source
Genome sequence and genetic linkage analysis of Shiitake mushroom _Lentinula edodes_ [PDF]
, 2012 _Lentinula edodes_ (Shiitake/Xianggu) is an important cultivated mushroom. Understanding the genomics and functional genomics of _L. edodes_ allows us to improve its cultivation and quality.
Chun Hang Au +10 more
core +2 more sources
Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs. [PDF]
, 2010 BackgroundIdiopathic epilepsy in the Belgian shepherd dog is known to have a substantial genetic component. The objective of this study was to identify genomic regions associated with the expression of generalized seizures in the Belgian Tervuren and ...
Belanger, Janelle M +4 more
core +3 more sources