Results 101 to 110 of about 283,128 (311)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Role of Human Twin Studies to Identify Genetic Linkage of Malaria Pathogenesis and Outcomes. [PDF]

Am J Trop Med Hyg, 2023
Biswas S, Nain M, Ahmad SS, Sharma A.
europepmc   +1 more source

LINKAGE OF GENETIC UNITS OF BACILLUS SUBTILIS IN DNA TRANSFORMATION [PDF]

, 1961
Eugene W. Nester, Joshua Lederberg
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

A genetic linkage map and improved genome assembly of the termite symbiont Termitomyces cryptogamus. [PDF]

BMC Genomics, 2023
Vreeburg SME, Auxier B, Jacobs B, Bourke PM, van den Heuvel J, Zwaan BJ, Aanen DK.   +6 more
europepmc   +1 more source

Wild-Type Strain of Staphylococcus aureus Containing Two Genetic Linkage Groups for Penicillinase Production [PDF]

, 1968
Helen M. Sweeney, Sidney Cohen
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Determinants of variation in serum paraoxonase enzyme activity in baboons

Journal of Lipid Research, 2005
Paraoxonase (PON), an HDL-associated enzyme, is one of many circulating antioxidants thought to play a vital protective role. To better understand the determinants of quantitative variation in serum PON activity, we assayed PON in samples from 611 ...
David L. Rainwater, Michael C. Mahaney, Xing Li Wang, Jeffrey Rogers, Laura A. Cox, John L. VandeBerg   +5 more
doaj  

Construction of a genetic linkage map and QTL mapping of fruit quality traits in guava (Psidium guajava L.). [PDF]

Front Plant Sci, 2023
Maan SS, Brar JS, Mittal A, Gill MIS, Arora NK, Sohi HS, Chhuneja P, Dhillon GS, Singh N, Thakur S.   +9 more
europepmc   +1 more source

EFFECT OF LINKAGE ON THE GENETIC LOAD MANIFESTED UNDER INBREEDING [PDF]

, 1965
Masatoshi Nei
openalex   +1 more source