Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study [PDF]
, 2005 Juvenile rheumatoid arthritis (JRA) comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability.
Bukulmez, H +9 more
core +2 more sources
The effect of linkage on establishment and survival of locally beneficial mutations [PDF]
Genetics 197, 317-336 (2014), 2013 When organisms adapt to spatially heterogeneous environments, selection may drive divergence at multiple genes. If populations under divergent selection also exchange migrants, we expect genetic differentiation to be high at selected loci, relative to the baseline caused by migration and genetic drift.
arxiv +1 more source
A comparison of SNPs and microsatellites as linkage mapping markers: lessons from the zebra finch (Taeniopygia guttata) [PDF]
, 2010 Background: Genetic linkage maps are essential tools when searching for quantitative trait loci (QTL). To maximize genome coverage and provide an evenly spaced marker distribution a combination of different types of genetic marker are sometimes used.
Ball, A.D. +5 more
core +3 more sources
Bioinform., 2012 Summary: GenAlEx: Genetic Analysis in Excel is a cross-platform package for population genetic analyses that runs within Microsoft Excel. GenAlEx offers analysis of diploid codominant, haploid and binary genetic loci and DNA sequences.
R. Peakall, P. Smouse
semanticscholar +1 more source
Genome Assembly Improvement and Mapping Convergently Evolved Skeletal Traits in Sticklebacks with Genotyping-by-Sequencing. [PDF]
, 2015 Marine populations of the threespine stickleback (Gasterosteus aculeatus) have repeatedly colonized and rapidly adapted to freshwater habitats, providing a powerful system to map the genetic architecture of evolved traits.
Glazer, Andrew M +4 more
core +1 more source
MapChart: software for the graphical presentation of linkage maps and QTLs.
Journal of Heredity, 2002 Over the last 15 years a wealth of linkage maps and quantitative trait loci (QTL) mapping results have become available. The pace of generating this genetic information is accelerating owing to advances in molecular marker technology and the development ...
R. Voorrips
semanticscholar +1 more source
Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'Drift mapping' in small populations with no demographic expansion [PDF]
, 1998 Linkage disequilibrium has been a powerful tool in identifying rare disease alleles in human populations. To date, most research has been directed to isolated populations which have undergone a bottleneck followed by rapid exponential expansion.
Laan, Maris +3 more
core +1 more source
High-dimensional statistical inference for linkage disequilibrium score regression and its cross-ancestry extensions [PDF]
arXiv, 2023 Linkage disequilibrium score regression (LDSC) has emerged as an essential tool for genetic and genomic analyses of complex traits, utilizing high-dimensional data derived from genome-wide association studies (GWAS). LDSC computes the linkage disequilibrium (LD) scores using an external reference panel, and integrates the LD scores with only summary ...
arxiv
Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype. [PDF]
, 2011 Background: Primary lymphoedema describes a chronic, frequently progressive, failure of lymphatic drainage. This disorder is frequently genetic in origin, and a multigenerational family in which eight individuals developed postnatal lymphoedema of all ...
Brice, G +11 more
core +3 more sources
Construction of multilocus genetic linkage maps in humans.
Proceedings of the National Academy of Sciences of the United States of America, 1987 Human genetic linkage maps are most accurately constructed by using information from many loci simultaneously. Traditional methods for such multilocus linkage analysis are computationally prohibitive in general, even with supercomputers.
E. Lander, P. Green
semanticscholar +1 more source