Results 181 to 190 of about 1,196,074 (333)

Stability of Nations and Genetic Diversity  [PDF]

open access: yes
This paper presents a model of nations where culturally heterogeneous agents vote on the optimal level of public spending. Larger nations benefit from increasing returns in the provision of public goods, but bear the costs of greater cultural ...
Ignacio Ortuno-Ortin   +3 more
core  

Genome Sequence Analysis of Auricularia heimuer Combined with Genetic Linkage Map [PDF]

open access: gold, 2020
Ming Fang   +7 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A genetic map of the chromatin regulators to drug response in cancer cells. [PDF]

open access: yesJ Transl Med, 2022
Chen B   +13 more
europepmc   +1 more source

Large-Scale Integration of Human Genetic and Physical Maps [PDF]

open access: hybrid, 2004
Caroline M. Nievergelt   +3 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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