Results 81 to 90 of about 4,905,945 (358)

Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects

open access: yesBMC Cardiovascular Disorders, 2003
Background Overweight is associated with an increased cardiovascular risk which is only partially explained by conventional risk factors. The objective of this study was to evaluate lipoprotein(a) [Lp(a)] plasma levels and apolipoprotein(a) [apo(a ...
Falcone Colomba   +6 more
doaj   +1 more source

Linkage disequilibrium estimates of contemporary Ne using highly variable genetic markers: a largely untapped resource for applied conservation and evolution

open access: yesEvolutionary Applications, 2009
Genetic methods are routinely used to estimate contemporary effective population size (Ne) in natural populations, but the vast majority of applications have used only the temporal (two‐sample) method.
R. Waples, C. Do
semanticscholar   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Searching for the Transcriptomic Signature of Immune Tolerance Induction—Biomarkers of Safety and Functionality for Tolerogenic Dendritic Cells and Regulatory Macrophages

open access: yesFrontiers in Immunology, 2018
The last years have witnessed a breakthrough in the development of cell-based tolerance-inducing cell therapies for the treatment of autoimmune diseases and solid-organ transplantation.
Juan Navarro-Barriuso   +5 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Satellyptus: analysis and database of microsatellites from ESTs of Eucalyptus

open access: yesGenetics and Molecular Biology, 2005
The main goal of our research was to search for SSRs in the Eucalyptus EST FORESTs database (using a software for mining SSR-motifs). With this objective, we created a database for cataloging Eucalyptus EST-derived SSRs, and developed a bioinformatics ...
Paulo Cezar Ceresini   +15 more
doaj   +1 more source

HLA-A*31:01 and HLA-B*15:02 as genetic markers for carbamazepine hypersensitivity in children

open access: yesClinical pharmacology and therapy, 2013
The occurrence of hypersensitivity reactions including rare but life‐threatening Stevens–Johnson syndrome (SJS) and drug‐induced hypersensitivity syndrome (HSS) limits the use of the anticonvulsant carbamazepine (CBZ).
U. Amstutz   +6 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

A dermatoglyphics of foot in the prognosis of sporting gift: differential distinctions of dermatoglyphics of foot for sportsmen and people which do not go in for sports

open access: yesPedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2013
The features of forming of dermatoglyphics of feet are compared for sportsmen and people, which do not go in for sports. In researches took part 209 men and 198 women in age 17-19 years, which did not go in for systematic sports.
L.P. Serhiyenko, V.M. Lyshevska
doaj  

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