Results 101 to 110 of about 1,070,803 (312)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Genetic markers as instrumental variables: an application to child fat mass and academic achievement [PDF]

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists. This paper examines the conditions that need to be met for genetic variants to be used as instruments.
Frank Windmeijer, Carol Propper, Stephanie von Hinke Kessler Scholder, George Davey Smith, Debbie A. Lawlor   +4 more
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Spontaneous gene flow and population structure in wild and cultivated chicory, Cichorium intybus L.

, 2008
Spontaneous gene flow between wild and cultivated chicory, Cichorium intybus L., may have implications for the genetic structure and evolution of populations and varieties.
Hauser, Thure P., Bagger Jørgensen, Rikke, Guadagnuola, R., Scotti, I., Jorgensen, R. B., Wiel, C., Kiær, L. P., I. Scotti, Hauser, T., JORGENSEN R. B., L. P. Kiær, FELBER F, GUIATTI, Denis, Kiær, L., R. Guadagnuolo, Kiaer, L.P., D. Guiatti, N. Syed, M. Vischi, Olivieri, A., KIAER L. P, T. P. Hauser, Kiaer, L. P., van de Wiel, C.C.M., van de Wiel, C., Jorgensen, R.B., SCOTTI I, C. van de Wiel, Flavell, A., F. Felber, Wiel, C. van de, VISCHI, Massimo, Vischi, M., Hauser, T.P., VAN DE VIEL C, Hauser, T. P., Kiær, Lars Pødenphant, SYED N, Guadagnuolo, Roberto, Guiatti, D., Jørgensen, R., OLIVIERI A. M, Scotti, Ivan, GUADAGNUOLO R, R. B. Jørgensen, Jørgensen, R.B., HAUSER T. P, Guadagnuolo, R., A. Flavell, Felber, F., Olivieri, A.M., Jørgensen, R. B., Hauser, Thure Pavlo, Olivieri, A. M., Syed, N., A. M. Olivieri, FLAVELL A, Felber, François, Wiel, C.C.M., van de   +58 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

PCR-SSCP of the 16S rRNA gene, a simple methodology for species identification of fish eggs and larvae

Scientia Marina, 2006
Patterns of the 16S rRNA gene obtained in 8 and 12% acrylamide gels by the SSCP (Single Strand Conformation Polymorphism) method were different for various marine fish species (Macrorhamphosus scolopax, Scomber scombrus, Lepidorhombus boscii, L ...
Eva Garcia-Vazquez, Paula Alvarez, Placida Lopes, Nikoletta Karaiskou, Juliana Perez, Ana Teia, José L. Martinez, Laurentina Gomes, Costas Triantaphyllidis   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Optimal Management of Genetic Diversity in Subdivided Populations

Frontiers in Genetics, 2019
One of the main objectives of conservation programs is the maintenance of genetic diversity because this provides the adaptive potential of populations to face new environmental challenges.
Eugenio López-Cortegano, Eugenio López-Cortegano, Ramón Pouso, Ramón Pouso, Adriana Labrador, Adriana Labrador, Andrés Pérez-Figueroa, Jesús Fernández, Armando Caballero, Armando Caballero   +9 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source