Results 61 to 70 of about 982,877 (263)

Human complex mixture analysis by “FD Multi-SNP Mixture Kit”

Frontiers in Genetics
IntroductionMultiple linked single nucleotide polymorphisms (SNPs) have shown potential in personal identification and mixture detection. However, the limited number of marker and sequencing errors have obstructed accurate DNA typing.MethodsTo develop ...
Anqi Chen, Lun Li, Lun Li, Junfei Zhou, Junfei Zhou, Tiantian Li, Tiantian Li, Chunyan Yuan, Hai Peng, Hai Peng, Chengtao Li, Chengtao Li, Suhua Zhang, Suhua Zhang   +13 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Serum microRNAs as peripheral markers of primary aldosteronism

Frontiers in Endocrinology
BackgroundPrimary aldosteronism (PA) is the principal cause of secondary hypertension; it leads to significantly elevated cardiovascular morbidity and mortality, but only a fraction of its cases ever get detected, partially due to diagnostic procedures ...
Nikita Makhnov, Nikita Makhnov, Nikita Makhnov, Fredrik Axling, Elham Barazeghi, Peter Stålberg, Tobias Åkerström, Tobias Åkerström, Per Hellman, Per Hellman   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Potential Biological and Genetic Links Between Dementia and Osteoporosis: A Scoping Review

Geriatrics
Background: The biological mediators for the epidemiologic overlap between osteoporosis and dementia are unclear. We undertook a scoping review of clinical studies to identify genetic and biological factors linked with these degenerative conditions ...
Abayomi N. Ogunwale, Paul E. Schulz, Jude K. des Bordes, Florent Elefteriou, Nahid J. Rianon   +4 more
doaj   +1 more source

THE INFLUENCE OF MARKERS CSN3 AND ETH10 ON MILK PRODUCTION PARAMETERS IN CZECH PIED CATTLE [PDF]

Journal of Central European Agriculture, 2005
There were observed milk production parameters in 5506 daughters of 37 Czech Pied cattle sires in our study. Sires were genotyped for markers CSN3 and ETH10.
Jitka KUČEROVÁ, Eva NĚMCOVÁ, Miloslava ŠTÍPKOVÁ, Irena VRTKOVÁ, Josef DVOŘÁK, Jan FRELICH, Josef BOUŠKA, Miroslav MARŠÁLEK   +7 more
doaj  

Deleção 22q11.2 em pacientes com defeito cardíaco conotruncal e fenótipo da síndrome da deleção 22q11.2 Deleción 22q11.2 en pacientes con defecto cardiaco conotruncal y fenotipo del síndrome de la deleción 22q11.2 22q11.2 deletion in patients with conotruncal heart defect and del22q syndrome phenotype

Arquivos Brasileiros de Cardiologia, 2009
FUNDAMENTO: A síndrome da deleção 22q11.2 é a mais freqüente síndrome de microdeleção humana. O fenótipo é altamente variável e caracterizado por defeito cardíaco conotruncal, dismorfias faciais, insuficiência velofaríngea, dificuldade de aprendizagem e ...
Sintia Iole Nogueira Belangero, Fernanda T.S. Bellucco, Leslie Domenici Kulikowski, Denise M. Christofolini, Mirlene C. S. P. Cernach, Maria Isabel Melaragno   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source