Results 41 to 50 of about 982,877 (263)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

GENETIC MARKERS OF NEGATIVE OUTCOMES OF THE ACUTE CORONARY SYNDROME

open access: yesРоссийский кардиологический журнал, 2014
Aim. To evaluate the relationship of 8 mononucleotide polymorphisms (MNP) with negative longterm prognosis of the acute coronary syndrome.Material and methods.
N. G. Lozhkina   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Genetic Relatedness Between Batur, Merino and Local Sheep Based on Random Amplyfied Polymorphism DNA Marker

open access: yesAnimal Production: Indonesian Journal of Animal Production, 2011
RAPD analysis to determine the diversity, status and genetic close relatioship Batur with Merino, Garut, Thin Tail and Fat Tail sheep genomic DNA was used in 27 Batur, 15 Merino, 17 Garut, 15 Thin Tails and Fat Tails animals.
Prayitno   +3 more
doaj  

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

open access: yes
Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Etude comparative de la diversité et de la structure génétique de populations sauvages de Phaseolus lunatus L. à l’aide des marqueurs enzymatiques et microsatellites [PDF]

open access: yesBiotechnologie, Agronomie, Société et Environnement, 2005
Comparative study of genetic diversity and structure of wild Phaseolus lunatus L. populations using enzymatic and microsatellite markers. Genetic diversity within and among Phaseolus lunatus L. var.
Baudoin JP., Ouédraogo M., Maquet A.
doaj  

Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects

open access: yesBMC Cardiovascular Disorders, 2003
Background Overweight is associated with an increased cardiovascular risk which is only partially explained by conventional risk factors. The objective of this study was to evaluate lipoprotein(a) [Lp(a)] plasma levels and apolipoprotein(a) [apo(a ...
Falcone Colomba   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genetic variability in the Skyros pony and its relationship with other Greek and foreign horse breeds

open access: yesGenetics and Molecular Biology, 2011
In Greece, seven native horse breeds have been identified so far. Among these, the Skyros pony is outstanding through having a distinct phenotype. In the present study, the aim was to assess genetic diversity in this breed, by using different types of ...
Elisabeth Bömcke   +2 more
doaj  

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