Results 31 to 40 of about 1,685,362 (303)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Tissue microarrays for testing basal biomarkers in familial breast cancer cases

open access: yesSão Paulo Medical Journal
CONTEXT AND OBJECTIVE: The proteins p63, p-cadherin and CK5 are consistently expressed by the basal and myoepithelial cells of the breast, although their expression in sporadic and familial breast cancer cases has yet to be fully defined.
Rozany Mucha Dufloth   +3 more
doaj   +1 more source

ESTIMATING RELATEDNESS USING GENETIC MARKERS [PDF]

open access: yesEvolution, 1989
A new method is described for estimating genetic relatedness from genetic markers such as protein polymorphisms. It is based on Grafen's (1985) relatedness coefficient and is most easily interpreted in terms of identity by descent rather than as a genetic regression. It has several advantages over methods currently in use: it eliminates a downward bias
David C, Queller, Keith F, Goodnight
openaire   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Differential introgression and the maintenance of species boundaries in an advanced generation avian hybrid zone [PDF]

open access: yes, 2016
Background: Evolutionary processes, including selection and differential fitness, shape the introgression of genetic material across a hybrid zone, resulting in the exchange of some genes but not others.
Kovach, Adrienne I.   +3 more
core   +4 more sources

Analysis of the Mitochondrial Genome in Podolian Cattle Breeds

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
Podolian cattle breeds are represented by: Romanian Grey Steppe, Iskar Grey (Bulgarian Grey), Istrian, Katerini, Ukrainian Grey and Hungarian Grey. The mitochondrial genome in cattle has a length of about 16,338 nucleotides. The majority of taurine mtDNA
Madalina Alexandra Davidescu   +6 more
doaj  

Framing Cutting-Edge Integrative Deep-Sea Biodiversity Monitoring via Environmental DNA and Optoacoustic Augmented Infrastructures

open access: yesFrontiers in Marine Science, 2022
Deep-sea ecosystems are reservoirs of biodiversity that are largely unexplored, but their exploration and biodiscovery are becoming a reality thanks to biotechnological advances (e.g., omics technologies) and their integration in an expanding network of ...
Sergio Stefanni   +17 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

ASSOCIATION OF SOME BIOCHEMICAL-GENETIC MARKERS WITH THE REPRODUCTION PARAMETERS OF THE BOTOSANI KARAKUL EWES

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
The paper describes some associative aspects of various biochemical-genetic markers with the reproduction activity in ewes of the Botosani Karakul breed.
GH. HRINCA   +6 more
doaj  

Analysis of the genetic diversity of Dragon fruit based on ISSR markers in Colombia

open access: yesBrazilian Journal of Biology, 2022
Selenicereus megalanthus H. is a tropical fruit belonging to the family Cactaceae, is rich in essential nutrients, antioxidants and bioactive components. It presents wide variability in different characteristics and a great demand in the market; however,
A. C. Morillo, M. S. Mora, Y. Morillo
doaj   +1 more source

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