Results 61 to 70 of about 1,005,916 (291)

Increased incidence of seronegative autoimmune hepatitis in children during SARS-CoV-2 pandemia period

open access: yesFrontiers in Immunology
BackgroundSeronegative autoimmune hepatitis in children is a rare but potentially severe disease, sometimes requiring liver transplantation. This type of hepatitis may be associated with various immunological and hematological disorders, ranging from ...
Muriel Schmutz   +25 more
doaj   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee   +9 more
wiley   +1 more source

Un Algoritmo Genético Especializado en Planeamiento de Redes de Distribución Parte I. Fundamentos Técnicos del Algoritmo [PDF]

open access: yesRevista Científica de Ingeniería Energética, 2011
The distribution network planning using natural techniques is an actual scientific thematic; specially GeneticAlgorithms. The representative mathematical model in this case has a lot of restrictions.
Raúl Nicolás Carvajal Pérez
doaj  

Neuroevolution on the Edge of Chaos

open access: yes, 2017
Echo state networks represent a special type of recurrent neural networks. Recent papers stated that the echo state networks maximize their computational performance on the transition between order and chaos, the so-called edge of chaos.
Beggs John M   +2 more
core   +1 more source

Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]

open access: yes, 2019
BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas   +5 more
core   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

A High-Level Petri Net Framework for Genetic Regulatory Networks

open access: yesJournal of Integrative Bioinformatics, 2007
To understand the function of genetic regulatory networks in the development of cellular systems, we must not only realise the individual network entities, but also the manner by which they interact.
Banks Richard, Steggles L. Jason
doaj   +1 more source

Genetic and Environmental Influences on the Affective Regulation Network: A Prospective Experience Sampling Analysis

open access: yesFrontiers in Psychiatry, 2018
Background: The study of networks of affective mental states that play a role in psychopathology may help model the influence of genetic and environmental risks.
Laila Hasmi   +10 more
doaj   +1 more source

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego   +10 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

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