Results 111 to 120 of about 418,825 (313)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
An accurate method for the PV Model identification based on a genetic algorithm and the interior-point method [PDF]
, 2014 Due to the PV module simulation requirements as well as recent applications of model-based controllers, the accurate photovoltaic (PV) model identification method is becoming essential to reduce the PV power losses effectively.
Alireza Maheri (16272944) +5 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
A Digital Technique for Online Identification and Tracking of Power System Harmonics Based on Real Coded Genetic Algorithm [PDF]
, 2006 Current and voltage waveforms of a distribution or a transmission system are not pure sinusoids. There are distortions in these waveforms that consist of a combination of the fundamental frequency, harmonics and high frequency transients.
Zamanan, N. +2 more
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
OPTIMIZING PROJECT TIME-COST-QUALITY BY USING GENETIC ALGORITHMS [PDF]
Project management causes the problem of efficient resource assignment, activity, time constraints and relationships between activities. Traditional scheduling methods like CPM and PERT are incomplete tools to use in practice because they do not consider
Ileana Ruxandra BADEA +1 more
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
The Generic Mathematical Model for Dynamic Genetic Algorithm Optimization [PDF]
, 2009 [[abstract]]According to the results of previous research, the genetic algorithm (GA) is a good technique for finding near-global optimal solutions for group optimization.
Chen-Fang Tsai
core
Parameter estimation for the stochastic SIS epidemic model [PDF]
, 2014 In this paper we estimate the parameters in the stochastic SIS epidemic model by using pseudo-maximum likelihood estimation (pseudo-MLE) and least squares estimation.
Greenhalgh, David +3 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source