Results 111 to 120 of about 3,837,457 (288)

Genetic parameter estimation and fine-mapping of milk-production traits and somatic cell score in Chinese Simmental cattle

Journal of Dairy Science
: Chinese Simmental cattle serve as an important dual-purpose breed in sustainable livestock systems. Despite their economic value, the genetic architecture underlying milk-production traits in this breed under temperate conditions remains poorly ...
Chunxiao Dong, Peipei Ma, Yongjie Tang, Haoqi Han, Siqian Chen, Jiazi Yang, Zhigang Sun, Wei Wang, Ying Yu, Shengli Li   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Compressed Linear Genetic Programming: Empirical

, 2008
Modularisation is of intrest to the EA community as a mechanism to allow evolution to address larger problems. Starting from basic elements modularisation could make it possible to reuse higher level functionalities discovered during the evolutionary ...
Parameter Study On
core  

Genetic Variability and Trait Associations in Ethiopian and Exotic Lentil (Lens culinaris) Germplasm

International Journal of Plant Biology
Yield is a complex trait influenced by multiple components and their genetic behavior. Therefore, this study was designed to understand the complex nature of yield by uncovering relationships among traits and estimating the genetic parameters of lentil ...
Nigussie Kefelegn, Solomon Benor, Gizachew Haile Gidamo, Asnake Fikre, Ming Pei You, Martin J. Barbetti   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

OPTIMIZING PROJECT TIME-COST-QUALITY BY USING GENETIC ALGORITHMS [PDF]

Project management causes the problem of efficient resource assignment, activity, time constraints and relationships between activities. Traditional scheduling methods like CPM and PERT are incomplete tools to use in practice because they do not consider
Ileana Ruxandra BADEA, Constanta-Nicoleta BODEA   +1 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Impact of Heat Stress on Milk Yield, Milk Fat-to-Protein Ratio, and Conception Rate in Thai–Holstein Dairy Cattle: A Phenotypic and Genetic Perspective

Animals
Heat stress severely affects dairy cattle production and reproduction performances in tropical regions. Genetic selection to maintain adequate yield and reproductive performance while enhancing their ability to withstand heat is essential for improving ...
Wuttigrai Boonkum, Watcharapong Teawyoneyong, Vibuntita Chankitisakul, Monchai Duangjinda, Sayan Buaban   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Estimation of Genetic Parameters for Egg Production and Clutch Traits in Lindian Chickens

Animals
To accelerate breeding progress for egg production traits in Lindian chickens, the genetic parameters for egg production and clutch-related traits in Lindian chickens were evaluated in the present study.
Jiacheng Liu, Fei Liang, Changsheng Sun, Xu Wang, Zhiyong Su, Yumao Li, Peng Luan, Zhiping Cao, Xue Bai, Li Leng   +9 more
doaj   +1 more source