Results 121 to 130 of about 359,644 (254)

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Effect of Cytochrome P450 2C9 genetic polymorphism on agomelatine metabolism <i>in vitro</i>. [PDF]

PeerJ
Fang P, Ni J, Shen T, Chen Q, Ye X, Jin J, Dai D, Hu G, Qian J, Cai J, Chen L.   +10 more
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Advanced Glycation End Products and Genetic Polymorphism in the Pathogenesis of Microvascular Complications in Type 2 Diabetes Mellitus: A Narrative Review. [PDF]

Cureus
Sarangi R, Singh S, Sahoo JP, Satpathy A.   +3 more
europepmc   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

Genetic polymorphism of SNPs rs9399137 and rs4895441in HBS1L-MYB and SNP rs766432 in BCL11A among β-thalassemia Egyptian patients. [PDF]

BMC Genom Data
Abdelrahman AA, Talaat RM, El-Halfawy IA, Alalwi MR, Rizk DMY.   +4 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Potential role of NLRP3 genetic polymorphism and gene expression in differentiating causes of neonatal cholestasis. [PDF]

Clin Exp Hepatol
Khalil FO, Nagi SAM, Waheed S, Elkholy SS, Khalil HAE, Abdelsattar S, Elgazzar AAEA, Elashkar AE.   +7 more
europepmc   +1 more source

Further Evidences for the Sulfur Spillover on Carbon: Thermodynamic Aspects and Effects on Li‐S Solid‐State Batteries

Advanced Science, EarlyView.
ABSTRACT This study investigates sulfur spillover, the spontaneous and rapid spread of sulfur over carbon surfaces at ambient temperature. The process is studied by small‐angle X‐ray scattering (SAXS), X‐ray radiography, and microcalorimetry from which a number of physicochemical properties are derived.
Francesco Piccolo, Anka Berger, Sebastian Risse, Román Healy Corominas, Wilhelm Erth, Florian Fuchs, Jesus Andrade, Jörg Schuster, Marc Armbrüster, Philipp Adelhelm   +9 more
wiley   +1 more source

EST-SSR based genetic polymorphism among Lablab (Lablab purpureus L. Sweet) accessions contrasting for drought stress at seedling stage. [PDF]

Sci Rep
Missanga JS, Ndakidemi PA, Venkataramana PB.   +2 more
europepmc   +1 more source